Visfatin Levels Before and After Periodontal Treatment

Completed

• Conditions: Periodontal Diseases
• Interventions: Procedure: Non-surgical Periodontal Treatment.

• Registration Number: NCT02615626
• Lead Sponsor: Bulent Ecevit University

Brief Summary

The purpose of this study was to evaluate visfatin levels in different stages of periodontal diseases and health, moreover the effect of non-surgical periodontal therapy on visfatin levels in Gingival Crevicular Fluid (GCF) and Serum.

Detailed Description

Total of 45 patients were divided into three groups based on their clinical and radiographical examination. Group 1 chronic periodontitis (n: 15), group 2 plaque induced gingivitis (n: 15) and group 3 Periodontal health (n: 15). GCF and serum samples were collected before treatment and 1, 3, 6 months after treatment and were assayed using enzyme linked immunosorbent assay kit.

Study Timeline

• Study Start: 2012-05
• Primary Completion: 2013-10
• Study Completion: 2014-01
• Status Verified: 2015-11
• Study First Submitted: 2015-11-23
• Study First Submitted QC: 2015-11-24
• Last Update Submitted: 2015-11-24
• Study First Posted: 2015-11-26
• Last Update Posted: 2015-11-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• GI>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically.
• Systematically healthy patients

Group 2 Inclusion Criteria:

• No alveolar bone and attachment loss
• Inflammation signs such as redness, edema and increased BOP levels,
• GI≥2, PPD≤3mm, CAL≤3mm.
• Systematically healthy patients

Group 3 Inclusion Criteria:

• No bone and attachment loss,
• GI=0, PPD≤3mm, CAL≤3mm
• Systematically healthy patients

Exclusion Criteria for all groups:

• Aggressive Periodontitis,
• Oral pathologies,
• Patients with any other systemic diseases,
• Pregnant women and those in the lactation period,
• Patients with smoking habit and taking medication
• Patients received periodontal therapy in last 6 months

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group 2	Non-surgical Periodontal Treatment.	Gingivitis, Non-surgical Periodontal Treatment
Group 1	Non-surgical Periodontal Treatment.	Periodontal healthy
Group 3	Non-surgical Periodontal Treatment.	Chronic Periodontitis, Non-surgical Periodontal Treatment

Primary Outcome Measures

Name	Time	Method
Visfatin levels: Change after periodontal treatment both in serum and GCF	baseline, 1, 3 and 6 months