The efficacy of Desmopressin Acetate in reduction of post kidney biopsy bleeding among renal insufficiency patients: A randomized controlled trial.

Phase 4

Recruiting

• Conditions: The patient with serum creatinine 1.5- 4 mg/dL who undergo native kidney biopsy.; kidney biopsy, complication, uremic bleeding, desmopressin, renal insufficiency

• Registration Number: TCTR20150203001
• Lead Sponsor: Siriraj Institutional Review Board Certificate of Approval

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-02-03
• Study Completion: 2015-06-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 154

Inclusion Criteria

1. Age >/= 18 years old
2. Native kidney
3. Creatinine >/= 1.5 to < 4 mg/dL
4. BP < 160/80 mmHg before kidney biopsy
5. Normal platelet count and coagulogram

Exclusion Criteria

1. Single kidney
2. Kidney cancer
3. Hydronephrosis or pyelonephritis
4. BMI > 35 kg/m2
5. Dialysis free time < 2 weeks in case indicated dialysis
6. Different kidney size more than 2 cm.
7. The patient who takes antiplatelets or anticoagulants
8. Allergy to DDAVP

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Minor bleeding complication: bleeding without blood transfusion nor intervention 6 hours, 24 hours after intervention hemoglobin, hematoma size by ultrasound,Major bleeding complication: bleeding with requirement of blood transfusion or intervention 6 hours, 24 hours after intervention hemoglobin, hematoma size by ultrasound, blood transfusion, angiogram with embolization

Secondary Outcome Measures

Name	Time	Method
hematoma size between 2 groups 6 hours ultrasound,the different between vWF Ag, RCO, CBA level between 2 groups 1 hour after DDAVP injection measurement of vWF Ag, RCO, CBA level,the different between platelet aggregation test between 2 groups 1 hour after DDAVP injection platelet aggregation test,side effect of DDAVP 6 hours after DDAVP injection plasma sodium