Retrospective Analysis of Organ Dysfunction Changes in Acute Necrotizing Pancreatitis Patients With Sepsis Following Open Necrosectomy：A Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 700
- 试验地点
- 1
- 主要终点
- Measure organ dysfunction change after open necrosectomy with respect to time
研究概览
简要总结
The purpose of this retrospective study was to characterize the changes in organ dysfunction among patients with acute necrotizing pancreatitis complicated by sepsis who underwent open necrosectomy.
详细描述
Baseline demographic and clinical characteristics (including age, gender, and education level) were collected from medical records. Organ dysfunction was defined according to the Sequential Organ Failure Assessment (SOFA) score. SOFA scores were extracted at predefined time points: preoperative (T1), postoperative day 1 (T2), postoperative day 3 (T3), and either postoperative day 7 or hospital discharge, whichever occurred first (T4). Postoperative survival status up to 1 year was obtained from the institutional database.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients 18 years or older
- •Diagnosis of Acute pancreatitis according to the revised Atlanta classification, requires two of thefollowing three criteria: (A) typical abdominal pain, (B) an increase in serum amylase or lipaselevels higher than three times the upper limit of normality, and (C) signs of AP in imaging3)Patients with confirmed or suspected infected pancreatic or peripancreatic necrosis werescheduled for open necrosectomy
- •Meet Sepsis-3 criteria
排除标准
- •Patients undergo repeat surgery on the same site
结局指标
主要结局
Measure organ dysfunction change after open necrosectomy with respect to time
时间窗: up to postoperative day 7, or at hospital discharge, whichever comes first
Organ dysfunction was assessed retrospectively using the Sequential Organ Failure Assessment (SOFA) score, which ranges from 0 (normal) to 4 (most abnormal) for each organ, with higher scores indicating more severe dysfunction.
次要结局
- Incidence of ICU mortality(an average of 1year)
- Incidence of 28-day mortality(an average of 1 year)
- ICU length of hospital stay(an average of 1 year)
- Incidence of hospital mortality(an average of 1 year)
- Incidence of one year mortality(an average of 1 year)
- Length of hospital stay(an average of 1 year)
研究者
Chunling Jiang
Professor
West China Hospital