Prevalence of Circulating Parvovirus Genome in Recently Diagnosed Graves' Disease: a Case-control Study

Not Applicable

Completed

• Conditions: Graves Disease
• Interventions: Biological: serodiagnosis

• Registration Number: NCT02798965
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Lymphocytic thyroiditis is the most common autoimmune disease, usually affecting young women. Although the aetiology and pathogenesis remain obscure, the most widely accepted hypothesis is an interaction between a genetic predisposition and an environmental trigger factor such as viral infection. Parvovirus infections have been proposed as trigger factors for Hashimoto's thyroiditis and Graves' disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-12
• Primary Completion: 2014-05
• Study Completion: 2014-05
• Status Verified: 2016-06
• Study First Submitted: 2016-06-09
• Study First Submitted QC: 2016-06-09
• Study First Posted: 2016-06-14
• Last Update Submitted: 2016-06-15
• Last Update Posted: 2016-06-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• Graves' disease :patients treated for Graves' disease, the diagnosis date less than 4 months
• Control : patients cared for nodules or goiter

Exclusion Criteria

• Patients undergoing immunosuppressive therapy including corticosteroids

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Graves' disease	serodiagnosis	patients with Graves' disease
Control	serodiagnosis	patients with goiter or nodule

Primary Outcome Measures

Name	Time	Method
prevalence of circulating parvovirus genome	Day 0

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France