Comparison of plain Ropivacaine versus Ropivacaine with different concentration of Dexmedetomidine in ultrasound guided supraclavicular block for Orthopedic forearm surgery-A prospective , randomised , comparative clinical study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- 1. Duration of analgesia
研究概览
简要总结
Supraclavicular block of brachial plexus is commonly used block for Orthopedic forearm surgery. Ropivacaine is local anaesthetic agent that block peripheral afferents acting on voltage gated sodium channel. It provide good operative condition but have shorter duration of postoperative analgesia and good cardiovascular safety. Hence various adjuvants were added to local anaesthetic in brachial plexus block to achieve quick, dense and prolonged block. Dexmedetomedine, an alpha2 agonist is an adjuvant to local anaesthetic in regional anaesthesia to enhance quality and duration of analgesia. Dose range of 0.5 - 2microgm/kg has been used in various studies. The aim of study is to enhance safety and efficacy of plain Ropivacaine with different concentrations of dexmedetomedine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Open Label
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.ASA grade 1 and 2 2.Both elective and emergengy surgeries.
- •3.Upper limb surgeries-elbow,forearm and hand 4.Patient able to give informed and written consent.
排除标准
- •1.Allergy or hypersensitivity to local anaesthtic agent
- •Patient with bleeding disorder or on anticoagulant therapy
- •Pregnant patient
- •Patient with major cardiovascular,respiratory ,renal,and liver disease
- •Patient taking opiod medicine.
结局指标
主要结局
1. Duration of analgesia
时间窗: 1. From end of surgery to pain on VAS OF 4 or more.. | 2. From onset of block to start of recovery
2. Duration of sensory and motor block
时间窗: 1. From end of surgery to pain on VAS OF 4 or more.. | 2. From onset of block to start of recovery
次要结局
- Adverse effects, sedation score, rescue analgesic(Every 2 hourly upto 24 hrs)