DRKS00013887招募中不适用
Respiratory muscle strength in patients with pulmonary arterial hypertension before and after effective treatment
Department für Neurologie - Klinik für Schlafmedizin und neuromuskuläre Erkrankungen0 个研究点目标入组 20 人开始时间: 2018年6月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •Invasively obtained diagnosis of PAH (mean pulmonary arterial pressure = 25 mmHg; post-capillary wedge pressure =15 mmHg; pulmonary vascular resistance > 3 Wood units) in accordance with the most recent guideline of the European Society of Cardiology (ESC)
- •-APAH due to (echocardiographically) proven congenital heart disease or due to (antinuclear antibody positive) connective tissue disease (systemic sclerosis) in accordance with the most recent guideline of the European Society of Cardiology (ESC)
- •-No or ineffective treatment (untreated”), as defined by no clinical improvement (NYHA functional class > II) and/or persistent elevation or no near-to-normal reduction of NT-proBNP levels under current PAH medication
- •-Age > 18 years
- •-Free ambulation
- •-Written informed consent to participate in the study
- •Additional inclusion criterion for post-treatment evaluation:
- •Positive treatment response as reflected by clinical improvement (NYHA I or II) and/or normal or near-to-normal of NT-proBNP.
排除标准
- •-Body Mass Index (BMI) > 35
- •-Heart failure with left ventricular ejection fraction <50%
- •-Chronic obstructive pulmonary disease, emphysema
- •-Presence of severe neurological comorbidities especially primary myopathy, muscular dystrophy, motor neuron disease, phrenic nerve disease, epilepsy, multiple sclerosis, parkinson’s disease
- •-Severe psychiatric disease including dementia
- •-Thoracic wall disease
- •-Cardiac pacemaker
研究者
相似试验
已完成
不适用
Respiratory muscle strength in pulmonary fibrosisJ84.1Other interstitial pulmonary diseases with fibrosisDRKS00000817niversitätsklinik FreiburgAbt. Pneumologie49
尚未招募
不适用
The Respiratory muscle strength assessment in long-term kidney disease patients who is undergoing Hemodialysis.CTRI/2022/08/044773Manjula M
进行中（未招募）
不适用
A Study of Respiratory Muscle Strength, including Effort-Independent Measures, in Subjects with Late-Onset Pompe DiseaseMedDRA version: 18.0Level: LLTClassification code 10036143Term: Pompe's diseaseSystem Organ Class: 100000004850Pompe diseaseEUCTR2014-002158-38-FRBioMarin Pharmaceutical Inc15
尚未招募
4 期
A Study of Respiratory Muscle Strength, including Effort-Independent Measures, in Subjects with Late-Onset Pompe DiseaseLate-onset Pompe disease10028302NL-OMON43764BioMarin Pharmaceutical Inc.5
已完成
不适用
Contribution of respiratory muscle strength and right ventricular pump function to exercise intolerance in patients with precapillary pulmonary hypertensioI27.0I27.20Primary pulmonary hypertensionDRKS00014695Institut für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster86