Respiratory muscle strength in pulmonary fibrosis
Completed
- Conditions
- J84.1Other interstitial pulmonary diseases with fibrosis
- Registration Number
- DRKS00000817
- Lead Sponsor
- niversitätsklinik FreiburgAbt. Pneumologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 49
Inclusion Criteria
histologically assessed pulmonary fibrosis in the patient group
Exclusion Criteria
Patients:
other lung diseases
right heart failure
diabetes mellitus
neuromuscular diseases
Control subjects
Lung diseases
severe cardiac disease
diabetes mellitus
neuromuscular diseases
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method One-time assessment of twitch mouth pressure after bilateral anterior magnetic stimulation as a measure of diaphragmatic strength using an automated shutter-occluded spirometer.
- Secondary Outcome Measures
Name Time Method One-time assessment of global respiratory muscle strength (PImax), respiratory drive (P0.1) and Sniff pressure at the mouth using an automated shutter-occluded spirometer. Correlation of respiatroy muscle strength with performance in the 6min walking test and diseas-specific laboratoy parameters (CCL18).
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular pathways link respiratory muscle weakness to idiopathic pulmonary fibrosis (IPF) progression?
How does respiratory muscle strength correlate with biomarkers like surfactant protein D in J84.1 interstitial lung disease?
What adverse events are associated with progressive respiratory muscle decline in IPF observational cohorts?
Which antifibrotic therapies (e.g., pirfenidone, nintedanib) show synergistic effects with respiratory muscle training in IPF?
How do genetic markers like TGF-β polymorphisms influence respiratory muscle function in DRKS00000817 study participants?