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Evaluation of the effect of adding ketamine in dose reduction of morphine with patient-controlled analgesia pump in postoperative analgesia after major abdominal surgery

Phase 2
Conditions
Pain after abdominal surgery.
Registration Number
IRCT201112128384N1
Lead Sponsor
Mashhad University of Medical Sciences
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Complete
Sex
All
Target Recruitment
115
Inclusion Criteria

Inclusion criterion:
• Adult patients who undergo midline laparotomy
Exclusion Criteria
• Patients with pain disorder
• Consumption of any narcotics and analgesics within a week before surgery
• Narcotics addicts
• Any contraindication in consumption of paracetamol, morphine or ketamine
• Consumption of psychotropic drugs
• Any non-midline incision or below umbilicus incisions
• Surgical procedures with pelvic tissue manipulation
• Noncompliant patients

Exclusion Criteria

Not provided

Study & Design

Study Type
interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Pain Intensity. Timepoint: Every 2 hours for 6 hours and then every 6 hours up to 48 hours. Method of measurement: Visual Analogue Scale.
Secondary Outcome Measures
NameTimeMethod
Delirium. Timepoint: During the first 48 hours at ward post operatively. Method of measurement: ICU_CAM scale.;Pain location. Timepoint: During the first 48 hours at ward post operatively. Method of measurement: Subjectively by patient.;Morphine side effects-Nausea. Timepoint: Within the first 24 hours after intervention. Method of measurement: Times of nausea.;Morphine side effects_Respiratory suppression. Timepoint: Within the first 48 hours after intervention. Method of measurement: Respiratory rate.;Incision location. Timepoint: After operation. Method of measurement: Anatomical description.;Operating time. Timepoint: Duration between induction and end of general anaesthesia. Method of measurement: Minutes.;Reason for surgical procedure. Timepoint: After operation. Method of measurement: Benign_Malignant, Explorative, Acute_Chronic, NOS.
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