Assess the effect of two drugs( ketamine and dexmedetomidine) on cranial nerve monitoring during brain surgery
Not Applicable
Completed
- Conditions
- Health Condition 1: C717- Malignant neoplasm of brain stem
- Registration Number
- CTRI/2019/08/020817
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 42
Inclusion Criteria
1.Age 18-60 years
2.ASA I-III
3.GCS 13 - 15
4.Patients undergoing elective neuro surgery for posterior fossa tumour, requiring intraoperative cranial nerve monitoring and having no evidence of raised ICP.
Exclusion Criteria
1.Patients with features of raised ICP
2.Severe cardiovascular diseases (such as heart block, heart failure, left ventricular dysfunction)
3.Significant pulmonary, renal, hepatic or neuromuscular disease,
4.Pre-op involvement of cranial nerves except VIIth nerve
5.History of chronic alcohol use
6.Defined allergy to any of study drugs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To assess the effect of ketamine and dexmedetomidine infusion on amplitude of corticobulbar MEP of the cranial nerves <br/ ><br>2.To assess the effect of ketamine and dexmedetomidine infusion on latency of corticobulbar MEP of the cranial nerves <br/ ><br>Timepoint: Baseline at induction, At 30 minutes, At 45 minutes, At 60 minutes, At start of tumour dissection, 15 minutes after starting tumour dissection, 30 minutes after starting tumour dissection, 45 minutes after starting tumour dissection, 60 minutes after starting tumour dissection, 75 minutes after starting tumour dissection, 90 minutes after starting tumour dissection, 105 minutes after starting tumour dissection, 120 minutes after starting tumour dissection, At haemostasis, End of procedure
- Secondary Outcome Measures
Name Time Method