Comparison of the effect of ketamine-propofol combination with ketamine-thiopental in improving depressive symptoms in patients undergoing electroconvulsive therapy
- Conditions
- Depression.Mood disorder due to known physiological condition with major depressive-like episodeF06.32
- Registration Number
- IRCT20211009052708N1
- Lead Sponsor
- Semnan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Includes: Diagnosis of moderate to severe depression episode affected by DSM-5
age at least 18 years
performance and willingness to provide written consent by patient or legal guardian
verbal IQ of 8.5 or greater
undergoing ECT treatment in the past six months To be caught
Inability to provide informed written consent in the absence of a legal guardian
primary psychotic or schizoaffective disorder
obsessive-compulsive disorder
concomitant diagnosis of multiple psychiatric disorders in axis one and two
anorexia nervosa
history of substance or alcohol dependence
sensitivity to Anesthesia drugs or contraindications for their administration
ECT in the last three months
contraindications for ECT such as organic brain diseases and dementia
major medical conditions that affect neuropsychological function
pregnancy or lack of proper contraception
breastfeeding
Occurrence of psychotic symptoms or exacerbation of depressive symptoms during the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Depression score in Beck questionnaire. Timepoint: Before the start of the first ECT session and at the end of the third and sixth sessions, the Beck Depression Inventory test is performed on all samples. Method of measurement: Beck Depression Inventory.
- Secondary Outcome Measures
Name Time Method Quality of life score. Timepoint: After the end of the treatment period. Method of measurement: Short questionnaire SF-12.