The Effect of ProHydrolase® on the Amino Acid, Intramuscular Anabolic Signaling, and Endocrine Response to Resistance Exercise in Trained Males

Not Applicable

Completed

• Conditions: Amino Acids

• Registration Number: NCT04144114
• Lead Sponsor: Deerland Enzymes

Brief Summary

To examine the amino acid absorption following acute resistance exercise between three supplemental treatments: 1) Whey Protein + ProHydrolase (WPH) 2) Whey Protein (W) and 3) Non-Caloric Placebo (PL). To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on the mTORC1 complex pathway. To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on circulating concentrations of endocrine biomarkers.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-08-01
• Primary Completion: 2018-12-07
• Study Completion: 2018-12-07
• Status Verified: 2019-10
• Study First Submitted: 2019-10-28
• Study First Submitted QC: 2019-10-29
• Last Update Submitted: 2019-10-29
• Study First Posted: 2019-10-30
• Last Update Posted: 2019-10-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• • At least one-year of resistance training experience

  • Free of any physical limitations (determined by health and activity questionnaire).
  • Between the ages of 18 and 35.
  • Ability to leg press a weight equivalent to 1.5 times their body mass

Exclusion Criteria

• • Inability to perform physical exercise (determined by health and activity questionnaire)

  • Taking any other nutritional supplement or performance enhancing drug (determined from health and activity questionnaire).
  • Physical injury preventing the athlete from participating in offseason training
  • Any chronic illness that causes continuous medical care

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Amino acid absorption	4 weeks	To examine the amino acid absorption following acute resistance exercise between three supplemental treatments: 1) Whey Protein + ProHydrolase (WPH) 2) Whey Protein (W) and 3) Non-Caloric Placebo (PL)
mTORC1 pathway	4 weeks	To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on the mTORC1 complex pathway
Endocrine markers	4 weeks	To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on circulating concentrations of endocrine biomarkers.

Trial Locations

Locations (1)

Lipscomb University; 🇺🇸 Nashville, Tennessee, United States