Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef

Not Applicable

• Conditions: Protein Absorption and Amino Acid Availability; Muscle Protein Synthesis; Meat Protein Supplements

• Registration Number: NCT02732353
• Lead Sponsor: Kasper Dideriksen

Brief Summary

To measure the absorption kinetics and postprandial amino acid availability after ingestion of minced beef compared with hydrolyzed beef in young males. Moreover, the basal muscle protein synthesis and the postprandial muscle protein synthetic response to minced beef and hydrolyzed beef ingestion are measured in young males. The postprandial muscle protein synthetic response is measured and compared during the early postprandial period (0-3 hours) after ingestion of the two meat products.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-03-30
• Study First Submitted QC: 2016-04-04
• Study First Posted: 2016-04-08
• Status Verified: 2016-11
• Study Start: 2016-11
• Last Update Submitted: 2016-11-07
• Last Update Posted: 2016-11-08
• Primary Completion: 2018-03
• Study Completion: 2018-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• Healthy
• Non-obese (BMI<30)

Exclusion Criteria

• Chronic medical disease
• >5 hour of exercise weekly, except light activities such as stretching/gymnastics and bike-riding/walking as transportation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Change in skeletal muscle protein fractional synthetic rate	During the postprandial period (0-3 hrs).	The fractional synthetic rate of skeletal muscle proteins (%/h) measured during the overnight fasted state and the postprandial state.

Secondary Outcome Measures

Name	Time	Method
Protein absorption	During the postprandial period (0-3 hrs).	The change in venous plasma ring-2H5-phenylalanine enrichment after ingestion of meat protein, reflects the protein absorption from the meat protein products.
Plasma amino acid concentration	During the postprandial period (0-3 hrs).	Change in venous plasma amino acid concentration after ingestion of meat protein.

Trial Locations

Locations (1)

Bispebjerg Hospital; 🇩🇰 Copenhagen NV, Denmark