The Impact of Protein Intake on Amino Acid and Protein Metabolism, and Performance During Intensified Training
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Change in 24h whole body protein balance
研究概览
简要总结
Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).
Our recent study using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 30% higher than the recommended protein intake.
The present study will investigate the impact of protein sufficiency on protein metabolism and performance during intensified training periods as a means to further our understanding of the nutritional requirements for the endurance athlete.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy, male, endurance-trained participants who have run regularly more than 45 km or 4.5 hours/week
- •Participants who are categorized at least "very good" based on a study by Shvartz & Reibold [40], in which peak rate of oxygen consumption(VO2 Peak) is used as an index. (i.e. the participants whose VO2peak is ≥57 ml/kg/min (18-24 y), ≥54 ml/kg/min (25-29 y), ≥52 ml/kg/min (30-34 y), ≥49 ml/kg/min (35-39 y), ≥47 ml/kg/min (40-44 y), ≥44 ml/kg/min (45-50 y) according to his age,
- •Participants who can cover 10 km in less than 60 min after the VO2peak test and 5 km Time trial on session
- •Participants will be 18-50 years old.
- •Participants are willing to abide by the compliance rules of this study
排除标准
- •Inability to meet health and physical activity guidelines according to the The Physical Activity Readiness Questionnaire for everyone.
- •Inability to adhere to any of the compliance rules judged by principal investigator or medical doctor
- •Regular tobacco use
- •Illicit drug use (e.g. growth hormone, testosterone, etc.)
研究组 & 干预措施
Normal protein intake
participants will receive the controlled-diet containing 0.8 g protein /kg/day and the test drink containing 0.14 g protein/kg/d.
干预措施: Normal (Dietary Supplement)
Moderate protein intake
participants will receive the controlled-diet containing 1.20 g protein /kg/day and the test drink containing 0.40 g protein/kg/d.
干预措施: Moderate (Dietary Supplement)
Moderate protein intake
participants will receive the controlled-diet containing 1.20 g protein /kg/day and the test drink containing 0.40 g protein/kg/d.
干预措施: Controlled-diet (Other)
Normal protein intake
participants will receive the controlled-diet containing 0.8 g protein /kg/day and the test drink containing 0.14 g protein/kg/d.
干预措施: Controlled-diet (Other)
High protein intake
participants will receive the controlled-diet containing 1.83 g protein /kg/day and the test drink containing 1.03 g protein/kg/d.
干预措施: High (Dietary Supplement)
High protein intake
participants will receive the controlled-diet containing 1.83 g protein /kg/day and the test drink containing 1.03 g protein/kg/d.
干预措施: Controlled-diet (Other)
结局指标
主要结局
Change in 24h whole body protein balance
时间窗: Difference between day 1 and day 4 whole body protein balance
Protein balance (mg/kg/d; protein synthesis - protein breakdown) will be measured using \[15N\]Glycine method on day 1 and day 4 to determine the change over the intensified training period to compare between protein levels
次要结局
- Change from baseline physical performance (5 km time trial) 5days after the beginning of training(5days after the beginning of training)
- change from baseline Physical performance (muscle strength) 5days after the beginning of training(5days after the beginning of training)
- change from baseline Physical Performance (muscle power) 5days after the beginning of training(5days after the beginning of training)
研究者
Daniel Moore
Associate professor
University of Toronto