Mycoprotein and Muscle Protein Synthetic Response

Not Applicable

Completed

• Conditions: Anabolic Response to Mycoprotein and Micronutrient Ingeston
• Interventions: Dietary Supplement: Mycoprotein ingestion

• Registration Number: NCT04084652
• Lead Sponsor: University of Exeter

Brief Summary

Dietary protein is vital for the preservation of health and optimal adaptation to training. However, traditional animal proteins come with a number of economic, environmental, and ethical issues. Accordingly, there is a need to develop an understanding of the utility of more sustainable non-animal derived dietary proteins to support our nutrition. Mycoprotein, produced by Quorn Foods™, has recently been shown to stimulate a greater anabolic response within skeletal muscle compared with milk protein, suggesting its utility within sports nutrition. However, it is unclear what accounted for the greater anabolic response of mycoprotein. One explanation could be the non-protein nutrients contained within mycoprotein (e.g. fibre, carbohydrate, fat or micronutrients).

Therefore, the present study will compare the muscle anabolic response between mycoprotein (MYC) as a whole food and the protein isolated from mycoprotein (PIM).

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-15
• Study First Submitted: 2019-09-06
• Study First Submitted QC: 2019-09-09
• Study First Posted: 2019-09-10
• Primary Completion: 2019-12-11
• Study Completion: 2019-12-11
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-26
• Last Update Posted: 2022-05-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

• BMI between 18 and 30.
• Resistance trained

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Exclusion Criteria

• Any metabolic impairments.
• Cardio/pulmonary diseases.
• Chronic use of over the counter pharmaceuticals
• A personal or family history of epilepsy, seizures or schizophrenia.
• Allergic to mycoprotein/Quorn/edible fungi/environmental mould products.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Mycoprotein	Mycoprotein ingestion	Mycoprotein in its full food matrix
Protein Isolated from Mycoprotein	Mycoprotein ingestion	Protein from mycoprotein isolated from the food matrix

Primary Outcome Measures

Name	Time	Method
Muscle protein synthesis	7.5 hours	The rate of synthesis of new muscle protein (Fractional Synthetic Rate %/h)

Secondary Outcome Measures

Name	Time	Method
Serum Insulin	7.5 hours	The levels of insulin in blood serum
Blood Glucose	7.5 hours	The levels of glucose in the blood
Plasma Amino Acid Kinetics	7.5 hours	The rate of appearance of amino acids ingested in the drink

Trial Locations

Locations (1)

University of Exeter; 🇬🇧 Exeter, United Kingdom