The Muscle Protein Synthetic Response Following the Ingestion of a Single Bolus of Algal Protein When Compared to Fungal Protein in Healthy Young Adults
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Muscle Metabolism
- Sponsor
- University of Exeter
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- Muscle Protein Synthesis
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Dietary protein intake is vital for the maintenance of skeletal muscle mass and health. The production of animal-based proteins sources is associated with growing environmental and ethical challenges. As such, sustainable alternatives are needed. Algae are sustainably produced high-protein sources and it is predicted that algae will become one of the most consumed proteins in the next decades. However, the effects of algae on the stimulation of muscle mass growth are unknown. Therefore, we aim to assess the rate of digestion and absorption, and the effects on muscle growth of two types of algae (spirulina and chlorella) when compared to a sustainable non-animal derived fungal reference protein (mycoprotein), a source known to elicit a robust anabolic response.
Investigators
Eligibility Criteria
Inclusion Criteria
- •BMI between 18.5 and 30
- •Recreationally active (\<3 times per week structured resistance exercise training)
Exclusion Criteria
- •Any metabolic impairment
- •Any cardiovascular impairment
- •High blood pressure (\>140/90 mmHg)
- •A personal history of epilepsy, seizures or schizophrenia
- •Chronic (\>1 month) use of over the counter pharmaceuticals
- •Chronic (\>2 months) use of amino acid or protein supplements
- •Allergic to Quorn/mycoprotein or algae products
Outcomes
Primary Outcomes
Muscle Protein Synthesis
Time Frame: 7.5 hours
The rate of synthesis of new muscle protein (Fractional Synthetic Rate %/h)
Secondary Outcomes
- Plasma Amino Acid Kinetics(7.5 hours)
- Blood Glucose(7.5 hours)
- Serum Insulin(7.5 hours)
- mTOR phosphorylation(7.5 hours)