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Clinical Trials/NCT04894747
NCT04894747
Completed
Not Applicable

Comparing Postprandial Muscle Protein Synthesis Rates Following the Consumption of Mycoprotein, Pea Protein and a Mycoprotein/Pea Protein Blend in Resistance Trained Individuals

University of Exeter1 site in 1 country33 target enrollmentMay 1, 2021

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Muscle Protein Synthesis
Sponsor
University of Exeter
Enrollment
33
Locations
1
Primary Endpoint
Muscle protein synthesis
Status
Completed
Last Updated
3 years ago

Overview

Brief Summary

Dietary protein is vital for the preservation of health and optimal adaptation to training. Plant proteins are considered inferior to animal proteins with respect to their ability to stimulate an acute muscle building response and therefore support long-term muscle reconditioning. Pea protein is a highly commercially available plant proteins source (available as supplements, food ingredients etc.), yet there is no research investigating its ability to stimulate a muscle building response. The investigators aim to assess the effect of consuming pea protein on muscle protein synthesis rates and compare these results to mycoprotein, a source known to elicit a robust anabolic response.

Pea protein is lower in some of the essential amino acids, namely methionine, which could mean it is less effective compared with mycoprotein which has a more complete amino acid profile. So in addition to comparing pea with mycoprotein, the investigators also want to compare to a blend of pea and mycoprotein to see if replenishing the amino acid content in pea 'rescues' the anabolic response.

Registry
clinicaltrials.gov
Start Date
May 1, 2021
End Date
June 15, 2022
Last Updated
3 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • BMI between 18 and 30
  • Resistance trained

Exclusion Criteria

  • Any metabolic impairment
  • Use of over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices).
  • A personal family history of epilepsy, seizures or schizophrenia.
  • Allergic to Quorn/mycoprotein/edible fungi/environmental mould products.
  • Any motor disorder.

Outcomes

Primary Outcomes

Muscle protein synthesis

Time Frame: 8.5 hours

The rate of synthesis of new muscle protein (Fractional synthetic rate %/h)

Secondary Outcomes

  • Serum insulin concentrations(8.5 hours)
  • mTOR phosphorylation via ATP kinase assay(8.5 hours)
  • Translocation of mTOR via immunohistochemistry(8.5 hours)
  • Plasma amino acid kinetics(8.5 hours)

Study Sites (1)

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