Comparing Postprandial Muscle Protein Synthesis Rates Following the Consumption of Mycoprotein, Pea Protein and a Mycoprotein/Pea Protein Blend in Resistance Trained Individuals
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Muscle Protein Synthesis
- Sponsor
- University of Exeter
- Enrollment
- 33
- Locations
- 1
- Primary Endpoint
- Muscle protein synthesis
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Dietary protein is vital for the preservation of health and optimal adaptation to training. Plant proteins are considered inferior to animal proteins with respect to their ability to stimulate an acute muscle building response and therefore support long-term muscle reconditioning. Pea protein is a highly commercially available plant proteins source (available as supplements, food ingredients etc.), yet there is no research investigating its ability to stimulate a muscle building response. The investigators aim to assess the effect of consuming pea protein on muscle protein synthesis rates and compare these results to mycoprotein, a source known to elicit a robust anabolic response.
Pea protein is lower in some of the essential amino acids, namely methionine, which could mean it is less effective compared with mycoprotein which has a more complete amino acid profile. So in addition to comparing pea with mycoprotein, the investigators also want to compare to a blend of pea and mycoprotein to see if replenishing the amino acid content in pea 'rescues' the anabolic response.
Investigators
Eligibility Criteria
Inclusion Criteria
- •BMI between 18 and 30
- •Resistance trained
Exclusion Criteria
- •Any metabolic impairment
- •Use of over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices).
- •A personal family history of epilepsy, seizures or schizophrenia.
- •Allergic to Quorn/mycoprotein/edible fungi/environmental mould products.
- •Any motor disorder.
Outcomes
Primary Outcomes
Muscle protein synthesis
Time Frame: 8.5 hours
The rate of synthesis of new muscle protein (Fractional synthetic rate %/h)
Secondary Outcomes
- Serum insulin concentrations(8.5 hours)
- mTOR phosphorylation via ATP kinase assay(8.5 hours)
- Translocation of mTOR via immunohistochemistry(8.5 hours)
- Plasma amino acid kinetics(8.5 hours)