The Effect of a Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis

Not Applicable

Completed

• Conditions: Muscle Metabolism
• Interventions: Behavioral: Bilateral resistance exercise; Dietary Supplement: Plant-blend protein; Dietary Supplement: Whey protein

• Registration Number: NCT06129513
• Lead Sponsor: University of Exeter

Brief Summary

Dietary protein ingestion is required to maximise the anabolic response during the recovery from resistance exercise. Whey protein is considered the optimal dietary strategy to maximise post-exercise muscle protein synthesis, but animal-protein production and consumption is associated with growing environmental and ethical concerns. Plant-based protein sources are considered of lesser anabolic quality than isonitrogenous boluses of animal-derived protein attributed to, at least in part, deficiencies in key essential amino acid. Blending different protein sources may overcome amino acid deficiencies and potentiate the post-exercise anabolic response. In the present study the investigators assessed the post-exercise muscle protein synthetic response following the ingestion of a novel plant-based protein isolate when compared with an isonitrogenous bolus of whey protein in healthy young, resistance trained women and men.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-02-24
• Primary Completion: 2022-10-31
• Study Completion: 2022-10-31
• Study First Submitted: 2023-09-20
• Status Verified: 2023-11
• Study First Submitted QC: 2023-11-08
• Last Update Submitted: 2023-11-08
• Study First Posted: 2023-11-13
• Last Update Posted: 2023-11-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• BMI between 18 - 30
• Resistance trained (>3 times per week structured resistance exercise training for at least 3 months)

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Exclusion Criteria

• Any metabolic impairment
• Any cardiovascular impairment
• Smoking
• Lactose intolerance
• Allergies to products containing dairy, meat or nuts
• Prescribed intake of over the counter pharmaceuticals

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Plant-blend isolate	Bilateral resistance exercise	Following a bout of bilateral resistance exercise, participants will ingest 32 g protein from a novel plant-blend protein isolate
Plant-blend isolate	Plant-blend protein	Following a bout of bilateral resistance exercise, participants will ingest 32 g protein from a novel plant-blend protein isolate
Whey protein isolate	Bilateral resistance exercise	Following a bout of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate
Whey protein isolate	Whey protein	Following a bout of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate

Primary Outcome Measures

Name	Time	Method
Post-exercise myofibrillar protein synthesis following protein ingestion	4 hours	The fractional synthetic rate of myofibrillar proteins

Secondary Outcome Measures

Name	Time	Method
Plasma amino acid response	4 hours	Post-exercise and postprandial change in plasma amino acid concentrations and availability
Post-exercise myofibrillar protein synthesis during the early postprandial period	2 hours	The fractional synthetic rate of myofibrillar proteins
Serum insulin response	4 hours	Post-exercise and postprandial change in serum insulin concentrations
Post-exercise myofibrillar protein synthesis during the late postprandial period	2 hours	The fractional synthetic rate of myofibrillar proteins

Trial Locations

Locations (1)

University of Exeter; 🇬🇧 Exeter, United Kingdom