Protein Requirements in Endurance-trained Athlete

Early Phase 1

Completed

• Conditions: Healthy; Increased Metabolic Requirement
• Interventions: Dietary Supplement: amino acids intake

• Registration Number: NCT02478801
• Lead Sponsor: University of Toronto

Brief Summary

Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).

Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.

Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than RDA based on nitrogen balance data.

Therefore, the purpose of this study is to measure the protein requirement in endurance trained adults using the IAAO technique.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-03
• Study First Submitted: 2015-06-18
• Study First Submitted QC: 2015-06-18
• Study First Posted: 2015-06-23
• Primary Completion: 2016-01
• Study Completion: 2016-05
• Status Verified: 2016-06
• Last Update Submitted: 2016-06-15
• Last Update Posted: 2016-06-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 9

Inclusion Criteria

• Healthy, male, endurance-trained participants who regularly more than 40 km/week
• Ability to perform the exercise stimulus (20 km run) on metabolic trial.

Exclusion Criteria

• Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+)
• Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
• Regular tobacco use
• Illicit drug use

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Endurance trained	amino acids intake	subjects will receive different levels of amino acids intakes varying from 0.2 to 2.8 g/kg/day.

Primary Outcome Measures

Name	Time	Method
13CO2 (carbon dioxide) excretion (μmol/kg/h)	4 hours / study day

Secondary Outcome Measures

Name	Time	Method
[13C]phenylalanine oxidation (μmol/kg/h)	4 hours/study day