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Clinical Trials/NCT06431334
NCT06431334
Recruiting
Not Applicable

Protein Requirements Amongst Male Masters-Level Athletes Following a Cycling Exercise Bout as Determined by the Indicator Amino Acid Oxidation Technique

McGill University2 sites in 1 country8 target enrollmentJune 21, 2024

Overview

Phase
Not Applicable
Intervention
Amino Acid Intake
Conditions
Healthy
Sponsor
McGill University
Enrollment
8
Locations
2
Primary Endpoint
13CO2 Excretion
Status
Recruiting
Last Updated
2 months ago

Overview

Brief Summary

Masters level cyclists are a population above the age of 35 years who frequently participate in prolonged as well as heavy-volume training. Like most endurance-trained athletes, a greater recommended dietary allowance (RDA) for protein of 1.2-1.4 g/kg/bw is suggested.

Dietary protein intake is vital for maximizing the benefits of training and ensuring optimal recovery. Dietary recommendations traditionally have been determined through nitrogen balance techniques, however, recent research indicates how this method is potentially underestimating protein requirements. Therefore, there is a need to reassess current dietary recommendations in order to meet the demands of physical activity for highly active populations.

Recent efforts to understand protein requirements during rest and following exercise have been completed using the indicator amino acid technique (IAAO). This non-invasive method is reported to provide a robust measure of protein requirements. However, there is limited work in older (≥60 years) active populations.

The purpose of this study is to measure the protein requirements in master cyclists, following an endurance training session, using the non-invasive IAAO technique.

Registry
clinicaltrials.gov
Start Date
June 21, 2024
End Date
June 1, 2026
Last Updated
2 months ago
Study Type
Interventional
Study Design
Single Group
Sex
Male

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Tyler Churchward-Venne

Associate Professor

McGill University

Eligibility Criteria

Inclusion Criteria

  • 18.5\< BMI \<35 kg/m\^2
  • Overtly healthy masters level cyclists ≥65 years
  • Masters level cyclist training (\>4 days per week; \~100 km per week)
  • Body mass stable over previous 6-months
  • Availability for multiple metabolic trials (\~7 trials)
  • Ability to travel to and from laboratory facility

Exclusion Criteria

  • Recent history of weight loss or weight gain (\>5% body weight)
  • Uncontrolled hypertension
  • ≥2 chronic diseases (e.g. diabetes, osteoporosis, dyslipidemia)
  • Acute illness that could affect protein metabolism (HIV, renal dysfunction, influenza)
  • Currently using anti-inflammatory medications
  • Inability to adhere to study protocol (i.e., alcohol, caffeine, dietary restrictions)
  • Regular tobacco user
  • Illicit drug use
  • Habitually ingesting ≥3 g/kg/bw

Arms & Interventions

Masters Level Cyclists

Participants are to be randomly assigned varying levels of amino acid intakes ranging between 0.2 to 2.8 g/kg/d

Intervention: Amino Acid Intake

Outcomes

Primary Outcomes

13CO2 Excretion

Time Frame: 7-weeks

Measured by continuous-flow isotope ratio mass spectrometry

Secondary Outcomes

  • L[13C]phenylalanine Oxidation(7-weeks)

Study Sites (2)

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