S0424 - Carcinogens in Lung Tissue From Smokers (Closed to Entry as of 7/15/07) and Non-Smokers With Newly Diagnosed Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
- Conditions
- Lung Cancer
- Interventions
- Genetic: chromogenic in situ hybridizationGenetic: gene expression analysisGenetic: mutation analysisGenetic: polymerase chain reactionGenetic: polymorphism analysisOther: fluorescent antibody techniqueOther: immunohistochemistry staining methodOther: laboratory biomarker analysisOther: matrix-assisted laser desorption/ionization time of flight mass spectrometryOther: study of socioeconomic and demographic variablesProcedure: study of high risk factors
- Registration Number
- NCT00450281
- Lead Sponsor
- SWOG Cancer Research Network
- Brief Summary
RATIONALE: Studying samples of blood and tissue from smokers (closed to entry as of 7/15/07) and non-smokers with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about risk factors for lung cancer and may help the study of cancer in the future.
PURPOSE: This clinical trial is studying carcinogens in lung tissue from smokers (closed to entry as of 7/15/07) and non-smokers with newly diagnosed stage I, stage II, or stage III non-small cell lung cancer.
- Detailed Description
OBJECTIVES:
* Assess lung tissue from patients with stage I, stage II, stage IIIA, or stage IIIB non-small cell lung cancer for specific tobacco smoke carcinogens (including polycyclic aromatic hydrocarbons \[PAH\] and DNA adducts, alterations in specific genes, including p53 and K-ras, and expression of HER2 and estrogen receptors α and β).
* Determine whether tobacco smoke carcinogens differ by gender and smoking status, adjusting for potential exposures and influential factors, including family smoking status, medication use, and hormonal and reproductive factors.
* Measure the levels of PAH-DNA adducts in lymphocytes and lung tissue and examine correlations between the two tissue sources.
* Determine whether DNA damage levels in tissue as well as in lymphocytes are higher in females than in males for the same level of smoking.
* Determine polymorphisms in several genes involved in the metabolism of the specific carcinogens investigated and in steroidogenesis and metabolism.
* Summarize patient self-report questionnaire data on active and passive smoking, other carcinogenic exposures, smoking preference, economic and educational status, family smoking status, reproductive factors, weight loss, and medication use by categories of male versus female and never-smoker versus ever-smoker.
OUTLINE: This is a case-series, multicenter study. Patients are stratified according to gender and smoking status (never smoker \[\< 100 cigarettes smoked during lifetime\] vs ever smoker \[≥ 100 cigarettes smoked during lifetime\] \[closed to accrual as of 7/15/07\]).
Patients complete the Lung Cancer Epidemiology Questionnaire for detailed assessment of the following:
* Exposure to active and passive smoke
* Occupational exposures
* Reproductive and hormonal risk factors
* Weight loss
* Economic and educational status
* Family smoking status
* Medication use
* Other variables relevant for the analysis (e.g., HER2, estrogen receptor status) Peripheral blood samples are collected for research studies. Previously collected tissue samples are also studied in the laboratory. Samples are examined for DNA adduct levels. Estrogen receptor α and β are assessed by immunohistochemistry (IHC). HER2 expression and amplification are measured by chromogenic in situ hybridization. IHC and DNA-polymerase chain reaction (PCR)-single-stranded conformational polymorphism assay are used to analyze p53 mutations. RAS mutations are analyzed with restriction fragment length polymorphism-PCR assay. Polycyclic aromatic hydrocarbons and 4-aminobiphenyl-DNA damage are assessed by IHC and immunofluorescence. Matrix-assisted laser desorption/ionization time of flight mass spectrometry is used to genotype polymorphisms, including CYP1A1, CYP1B1, GSTM1, GSTP1, MPO, NAT-1, NAT-2, CYP19, CYP17, SULT1A1.
Patients are followed annually for up to 5 years.
PROJECTED ACCRUAL: A total of 900 patients will be accrued for this study (female and male smoker strata closed to accrual as of 7/15/07).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 981
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Male, Never-smokers polymorphism analysis Male subjects who smoked less than 100 cigarettes during their lifetime. Male, Ever-smokers polymerase chain reaction Male subjects who have smoked at least 100 cigarettes during their lifetime. Male, Ever-smokers study of high risk factors Male subjects who have smoked at least 100 cigarettes during their lifetime. Female, Ever-smokers mutation analysis Female subjects who have smoked less than 100 cigarettes during their lifetime. Male, Never-smokers mutation analysis Male subjects who smoked less than 100 cigarettes during their lifetime. Male, Never-smokers laboratory biomarker analysis Male subjects who smoked less than 100 cigarettes during their lifetime. Male, Never-smokers study of high risk factors Male subjects who smoked less than 100 cigarettes during their lifetime. Male, Never-smokers polymerase chain reaction Male subjects who smoked less than 100 cigarettes during their lifetime. Male, Never-smokers fluorescent antibody technique Male subjects who smoked less than 100 cigarettes during their lifetime. Male, Ever-smokers mutation analysis Male subjects who have smoked at least 100 cigarettes during their lifetime. Male, Ever-smokers immunohistochemistry staining method Male subjects who have smoked at least 100 cigarettes during their lifetime. Male, Never-smokers matrix-assisted laser desorption/ionization time of flight mass spectrometry Male subjects who smoked less than 100 cigarettes during their lifetime. Male, Ever-smokers fluorescent antibody technique Male subjects who have smoked at least 100 cigarettes during their lifetime. Female, Ever-smokers polymerase chain reaction Female subjects who have smoked less than 100 cigarettes during their lifetime. Female, Ever-smokers immunohistochemistry staining method Female subjects who have smoked less than 100 cigarettes during their lifetime. Male, Never-smokers immunohistochemistry staining method Male subjects who smoked less than 100 cigarettes during their lifetime. Male, Ever-smokers chromogenic in situ hybridization Male subjects who have smoked at least 100 cigarettes during their lifetime. Male, Never-smokers chromogenic in situ hybridization Male subjects who smoked less than 100 cigarettes during their lifetime. Male, Never-smokers gene expression analysis Male subjects who smoked less than 100 cigarettes during their lifetime. Female, Ever-smokers polymorphism analysis Female subjects who have smoked less than 100 cigarettes during their lifetime. Female, Ever-smokers fluorescent antibody technique Female subjects who have smoked less than 100 cigarettes during their lifetime. Female, Ever-smokers laboratory biomarker analysis Female subjects who have smoked less than 100 cigarettes during their lifetime. Female, Ever-smokers study of high risk factors Female subjects who have smoked less than 100 cigarettes during their lifetime. Female, Never-smokers polymerase chain reaction Female subjects who have smoked at least 100 cigarettes during their lifetime. Female, Never-smokers fluorescent antibody technique Female subjects who have smoked at least 100 cigarettes during their lifetime. Male, Never-smokers study of socioeconomic and demographic variables Male subjects who smoked less than 100 cigarettes during their lifetime. Male, Ever-smokers gene expression analysis Male subjects who have smoked at least 100 cigarettes during their lifetime. Male, Ever-smokers polymorphism analysis Male subjects who have smoked at least 100 cigarettes during their lifetime. Male, Ever-smokers laboratory biomarker analysis Male subjects who have smoked at least 100 cigarettes during their lifetime. Female, Ever-smokers chromogenic in situ hybridization Female subjects who have smoked less than 100 cigarettes during their lifetime. Female, Ever-smokers gene expression analysis Female subjects who have smoked less than 100 cigarettes during their lifetime. Female, Ever-smokers matrix-assisted laser desorption/ionization time of flight mass spectrometry Female subjects who have smoked less than 100 cigarettes during their lifetime. Female, Ever-smokers study of socioeconomic and demographic variables Female subjects who have smoked less than 100 cigarettes during their lifetime. Female, Never-smokers chromogenic in situ hybridization Female subjects who have smoked at least 100 cigarettes during their lifetime. Female, Never-smokers mutation analysis Female subjects who have smoked at least 100 cigarettes during their lifetime. Male, Ever-smokers matrix-assisted laser desorption/ionization time of flight mass spectrometry Male subjects who have smoked at least 100 cigarettes during their lifetime. Female, Never-smokers gene expression analysis Female subjects who have smoked at least 100 cigarettes during their lifetime. Female, Never-smokers polymorphism analysis Female subjects who have smoked at least 100 cigarettes during their lifetime. Female, Never-smokers immunohistochemistry staining method Female subjects who have smoked at least 100 cigarettes during their lifetime. Female, Never-smokers study of high risk factors Female subjects who have smoked at least 100 cigarettes during their lifetime. Male, Ever-smokers study of socioeconomic and demographic variables Male subjects who have smoked at least 100 cigarettes during their lifetime. Female, Never-smokers matrix-assisted laser desorption/ionization time of flight mass spectrometry Female subjects who have smoked at least 100 cigarettes during their lifetime. Female, Never-smokers laboratory biomarker analysis Female subjects who have smoked at least 100 cigarettes during their lifetime. Female, Never-smokers study of socioeconomic and demographic variables Female subjects who have smoked at least 100 cigarettes during their lifetime.
- Primary Outcome Measures
Name Time Method DNA adduct levels End of study Tumor tissue alterations End of study
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (404)
Good Samaritan Regional Health Center
🇺🇸Mount Vernon, Illinois, United States
Fisher-Titus Medical Center
🇺🇸Norwalk, Ohio, United States
Mount Carmel Health - West Hospital
🇺🇸Columbus, Ohio, United States
Providence Cancer Center
🇺🇸Anchorage, Alaska, United States
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
🇺🇸Hartford, Connecticut, United States
Creticos Cancer Center at Advocate Illinois Masonic Medical Center
🇺🇸Chicago, Illinois, United States
Boston University Cancer Research Center
🇺🇸Boston, Massachusetts, United States
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
🇺🇸Seattle, Washington, United States
Polyclinic First Hill
🇺🇸Seattle, Washington, United States
Hennepin County Medical Center - Minneapolis
🇺🇸Minneapolis, Minnesota, United States
Good Samaritan Hospital Cancer Treatment Center
🇺🇸Cincinnati, Ohio, United States
Arizona Cancer Center at University of Arizona Health Sciences Center
🇺🇸Tucson, Arizona, United States
Utah Cancer Specialists at UCS Cancer Center
🇺🇸Salt Lake City, Utah, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
🇺🇸Ft. Smith, Arkansas, United States
Kaiser Permanente - Deer Valley
🇺🇸Antioch, California, United States
Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center
🇺🇸Burbank, California, United States
Cancer Care Center at John Muir Health - Concord Campus
🇺🇸Concord, California, United States
North Bay Cancer Center
🇺🇸Fairfield, California, United States
Kaiser Permanente - Fremont
🇺🇸Fremont, California, United States
Glendale Memorial Hospital Comprehensive Cancer Center
🇺🇸Glendale, California, United States
Kaiser Permanente Medical Center - Hayward
🇺🇸Hayward, California, United States
Tibotec Therapeutics - Division of Ortho Biotech Products, LP
🇺🇸Marysville, California, United States
Kaiser Permanente Medical Center - Oakland
🇺🇸Oakland, California, United States
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
🇺🇸Orange, California, United States
Valley Care Medical Center
🇺🇸Pleasanton, California, United States
Kaiser Permanente Medical Center - Redwood City
🇺🇸Redwood City, California, United States
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center
🇺🇸Pomona, California, United States
Kaiser Permanente Medical Center - Roseville
🇺🇸Roseville, California, United States
Kaiser Permanente Medical Center - Richmond
🇺🇸Richmond, California, United States
Kaiser Permanente Medical Center - San Francisco Geary Campus
🇺🇸San Francisco, California, United States
Kaiser Foundation Hospital - San Rafael
🇺🇸San Rafael, California, United States
Kaiser Permanente Medical Center - Santa Teresa
🇺🇸San Jose, California, United States
Kaiser Permanente Medical Center - Santa Rosa
🇺🇸Santa Rosa, California, United States
Kaiser Permanente Medical Center - Santa Clara Kiely Campus
🇺🇸Santa Clara, California, United States
Kaiser Permanente Medical Facility - Stockton
🇺🇸Stockton, California, United States
Kaiser Permanente Medical Center - South San Francisco
🇺🇸South San Francisco, California, United States
Kaiser Permanente Medical Center - Vallejo
🇺🇸Vallejo, California, United States
Kaiser Permanente Medical Center - Vacaville
🇺🇸Vacaville, California, United States
Tahoe Forest Cancer Center
🇺🇸Truckee, California, United States
Kaiser Permanente Medical Center - Walnut Creek
🇺🇸Walnut Creek, California, United States
John Muir/Mt. Diablo Comprehensive Cancer Center
🇺🇸Walnut Creek, California, United States
Memorial Hospital Cancer Center - Colorado Springs
🇺🇸Colorado Springs, Colorado, United States
Poudre Valley Hospital
🇺🇸Fort Collins, Colorado, United States
Kaiser Permanente - Denver
🇺🇸Denver, Colorado, United States
Front Range Cancer Specialists
🇺🇸Fort Collins, Colorado, United States
Kaiser Permanente - Lafayette
🇺🇸Lafayette, Colorado, United States
Sibley Memorial Hospital
🇺🇸Washington, District of Columbia, United States
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
🇺🇸Jupiter, Florida, United States
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
🇺🇸Fort Lauderdale, Florida, United States
CCOP - Mount Sinai Medical Center
🇺🇸Miami Beach, Florida, United States
Piedmont Hospital
🇺🇸Atlanta, Georgia, United States
Tallahassee Memorial Hospital
🇺🇸Tallahassee, Florida, United States
Northside Hospital Cancer Center
🇺🇸Atlanta, Georgia, United States
Robert and Carol Weissman Cancer Center at Martin Memorial
🇺🇸Stuart, Florida, United States
Saint Joseph's Hospital of Atlanta
🇺🇸Atlanta, Georgia, United States
CCOP - Atlanta Regional
🇺🇸Atlanta, Georgia, United States
WellStar Cobb Hospital
🇺🇸Austell, Georgia, United States
Northwest Community Hospital
🇺🇸Arlington Heights, Illinois, United States
Veterans Affairs Medical Center - Chicago Westside Hospital
🇺🇸Chicago, Illinois, United States
Decatur Memorial Hospital Cancer Care Institute
🇺🇸Decatur, Illinois, United States
La Grange Memorial Hospital
🇺🇸La Grange, Illinois, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
🇺🇸Maywood, Illinois, United States
Edward Hospital Cancer Center
🇺🇸Naperville, Illinois, United States
Hulston Cancer Center at Cox Medical Center South
🇺🇸Springfield, Missouri, United States
Hematology-Oncology Centers of the Northern Rockies - Billings
🇺🇸Billings, Montana, United States
SUNY Upstate Medical University Hospital
🇺🇸Syracuse, New York, United States
McDowell Cancer Center at Akron General Medical Center
🇺🇸Akron, Ohio, United States
Allegheny Cancer Center at Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Cancer Centers of the Carolinas - Grove Commons
🇺🇸Greenville, South Carolina, United States
Greenville Hospital Cancer Center
🇺🇸Greenville, South Carolina, United States
CCOP - Greenville
🇺🇸Greenville, South Carolina, United States
Cancer Centers of the Carolinas - Eastside
🇺🇸Greenville, South Carolina, United States
Cancer Centers of the Carolinas - Greer Radiation Oncology
🇺🇸Greer, South Carolina, United States
Huntsman Cancer Institute at University of Utah
🇺🇸Salt Lake City, Utah, United States
Fletcher Allen Health Care - University Health Center Campus
🇺🇸Burlington, Vermont, United States
Danville Regional Medical Center
🇺🇸Danville, Virginia, United States
St. Joseph Cancer Center
🇺🇸Bellingham, Washington, United States
Martha Jefferson Hospital Cancer Care Center
🇺🇸Charlottesville, Virginia, United States
St. Francis Hospital
🇺🇸Federal Way, Washington, United States
Franciscan Cancer Center at St. Joseph Medical Center
🇺🇸Tacoma, Washington, United States
Allenmore Hospital
🇺🇸Tacoma, Washington, United States
Harrison Poulsbo Hematology and Onocology
🇺🇸Poulsbo, Washington, United States
Good Samaritan Cancer Center
🇺🇸Puyallup, Washington, United States
Group Health Central Hospital
🇺🇸Seattle, Washington, United States
Cancer Care Northwest - Spokane South
🇺🇸Spokane, Washington, United States
Center for Cancer Treatment & Prevention at Sacred Heart Hospital
🇺🇸Eau Claire, Wisconsin, United States
Wenatchee Valley Medical Center
🇺🇸Wenatchee, Washington, United States
Marshfield Clinic - Chippewa Center
🇺🇸Chippewa Falls, Wisconsin, United States
Northwest Cancer Specialists at Vancouver Cancer Center
🇺🇸Vancouver, Washington, United States
Marshfield Clinic Cancer Care at Regional Cancer Center
🇺🇸Eau Claire, Wisconsin, United States
Holy Family Memorial Medical Center Cancer Care Center
🇺🇸Manitowoc, Wisconsin, United States
St. Mary's Hospital Medical Center - Green Bay
🇺🇸Green Bay, Wisconsin, United States
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
🇺🇸Green Bay, Wisconsin, United States
Bay Area Cancer Care Center at Bay Area Medical Center
🇺🇸Marinette, Wisconsin, United States
Marshfield Clinic - Indianhead Center
🇺🇸Rice Lake, Wisconsin, United States
Marshfield Clinic - Lakeland Center
🇺🇸Minocqua, Wisconsin, United States
Green Bay Oncology, Limited - Oconto Falls
🇺🇸Oconto Falls, Wisconsin, United States
Green Bay Oncology, Limited - Sturgeon Bay
🇺🇸Sturgeon Bay, Wisconsin, United States
Diagnostic and Treatment Center
🇺🇸Weston, Wisconsin, United States
Marshfield Clinic - Weston Center
🇺🇸Weston, Wisconsin, United States
West Allis Memorial Hospital
🇺🇸West Allis, Wisconsin, United States
Marshfield Clinic - Wausau Center
🇺🇸Wausau, Wisconsin, United States
Medcenter One Hospital Cancer Care Center
🇺🇸Bismarck, North Dakota, United States
Knight Cancer Institute at Oregon Health and Science University
🇺🇸Portland, Oregon, United States
CCOP - Columbia River Oncology Program
🇺🇸Portland, Oregon, United States
Providence Cancer Center at Providence Portland Medical Center
🇺🇸Portland, Oregon, United States
Adventist Medical Center
🇺🇸Portland, Oregon, United States
Providence St. Vincent Medical Center
🇺🇸Portland, Oregon, United States
Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center
🇺🇸Milwaukee, Wisconsin, United States
Regional Cancer Center at Memorial Medical Center
🇺🇸Springfield, Illinois, United States
CCOP - Carle Cancer Center
🇺🇸Urbana, Illinois, United States
Carle Cancer Center at Carle Foundation Hospital
🇺🇸Urbana, Illinois, United States
Saint Anthony Memorial Health Centers
🇺🇸Michigan City, Indiana, United States
Mercy Cancer Center at Mercy Medical Center - North Iowa
🇺🇸Mason City, Iowa, United States
McCreery Cancer Center at Ottumwa Regional
🇺🇸Ottumwa, Iowa, United States
Siouxland Hematology-Oncology Associates, LLP
🇺🇸Sioux City, Iowa, United States
CaroMont Cancer Center at Gaston Memorial Hospital
🇺🇸Gastonia, North Carolina, United States
Pardee Memorial Hospital
🇺🇸Hendersonville, North Carolina, United States
Charles B. Eberhart Cancer Center at DeKalb Medical Center
🇺🇸Decatur, Georgia, United States
Evanston Hospital
🇺🇸Evanston, Illinois, United States
Saint Anthony's Hospital at Saint Anthony's Health Center
🇺🇸Alton, Illinois, United States
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
🇺🇸Savannah, Georgia, United States
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
🇺🇸Savannah, Georgia, United States
University of Illinois Cancer Center
🇺🇸Chicago, Illinois, United States
Gwinnett Medical Center
🇺🇸Lawrenceville, Georgia, United States
Dwight David Eisenhower Army Medical Center
🇺🇸Fort Gordon, Georgia, United States
Southern Regional Medical Center
🇺🇸Riverdale, Georgia, United States
Harbin Clinic Cancer Center - Medical Oncology
🇺🇸Rome, Georgia, United States
Rush-Copley Cancer Care Center
🇺🇸Aurora, Illinois, United States
John B. Amos Cancer Center
🇺🇸Columbus, Georgia, United States
Northeast Georgia Medical Center
🇺🇸Gainesville, Georgia, United States
Reid Hospital & Health Care Services
🇺🇸Richmond, Indiana, United States
Genesis Regional Cancer Center at Genesis Medical Center
🇺🇸Davenport, Iowa, United States
Park Nicollet Cancer Center
🇺🇸Saint Louis Park, Minnesota, United States
Oakwood Cancer Center at Oakwood Hospital and Medical Center
🇺🇸Dearborn, Michigan, United States
Community Cancer Center of Monroe
🇺🇸Monroe, Michigan, United States
Mercy Memorial Hospital - Monroe
🇺🇸Monroe, Michigan, United States
Genesys Hurley Cancer Institute
🇺🇸Flint, Michigan, United States
Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
🇺🇸Robbinsdale, Minnesota, United States
CCOP - Metro-Minnesota
🇺🇸Saint Louis Park, Minnesota, United States
Green Bay Oncology, Limited - Escanaba
🇺🇸Escanaba, Michigan, United States
Mayo Clinic Cancer Center
🇺🇸Rochester, Minnesota, United States
Cancer Center of Kansas, PA - Pratt
🇺🇸Pratt, Kansas, United States
Saint Luke's East - Lee's Summit
🇺🇸Lee's Summit, Missouri, United States
CCOP - Cancer Research for the Ozarks
🇺🇸Springfield, Missouri, United States
Saint Louis University Cancer Center
🇺🇸Saint Louis, Missouri, United States
Providence Cancer Institute at Providence Hospital - Southfield Campus
🇺🇸Southfield, Michigan, United States
Liberty Hospital
🇺🇸Liberty, Missouri, United States
Cancer Center of Kansas - Fort Scott
🇺🇸Fort Scott, Kansas, United States
Cancer Center of Kansas, PA - Dodge City
🇺🇸Dodge City, Kansas, United States
David C. Pratt Cancer Center at St. John's Mercy
🇺🇸Saint Louis, Missouri, United States
Seton Cancer Institute at Saint Mary's - Saginaw
🇺🇸Saginaw, Michigan, United States
Missouri Baptist Cancer Center
🇺🇸Saint Louis, Missouri, United States
Arch Medical Services, Incorporated at Center for Cancer Care and Research
🇺🇸Saint Louis, Missouri, United States
Fairview Ridges Hospital
🇺🇸Burnsville, Minnesota, United States
St. Luke's Hospital Cancer Care Center
🇺🇸Duluth, Minnesota, United States
Midwest Hematology Oncology Group, Incorporated
🇺🇸Saint Louis, Missouri, United States
Saint Joseph Oncology, Incorporated
🇺🇸Saint Joseph, Missouri, United States
CCOP - St. Louis-Cape Girardeau
🇺🇸Saint Louis, Missouri, United States
Cancer Center of Kansas-Independence
🇺🇸Independence, Kansas, United States
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
Hutchinson Hospital Corporation
🇺🇸Hutchinson, Kansas, United States
Cancer Center of Kansas, PA - Kingman
🇺🇸Kingman, Kansas, United States
Hays Medical Center
🇺🇸Hays, Kansas, United States
Feist-Weiller Cancer Center at Louisiana State University Health Sciences
🇺🇸Shreveport, Louisiana, United States
Regional Cancer Center at Singing River Hospital
🇺🇸Pascagoula, Mississippi, United States
Lawrence Memorial Hospital
🇺🇸Lawrence, Kansas, United States
Cancer Center of Kansas, PA - Newton
🇺🇸Newton, Kansas, United States
Heartland Regional Medical Center
🇺🇸Saint Joseph, Missouri, United States
Van Elslander Cancer Center at St. John Hospital and Medical Center
🇺🇸Grosse Pointe Woods, Michigan, United States
Clemens Regional Medical Center
🇺🇸Mount Clemens, Michigan, United States
Caritas Holy Family Hospital
🇺🇸Methuen, Massachusetts, United States
Cancer Center of Kansas, PA - Chanute
🇺🇸Chanute, Kansas, United States
Cancer Center of Kansas, PA - Parsons
🇺🇸Parsons, Kansas, United States
Foote Memorial Hospital
🇺🇸Jackson, Michigan, United States
CCOP - Duluth
🇺🇸Duluth, Minnesota, United States
Hospital District Sixth of Harper County
🇺🇸Anthony, Kansas, United States
Menorah Medical Center
🇺🇸Overland Park, Kansas, United States
Saint Luke's Hospital - South
🇺🇸Overland Park, Kansas, United States
Mercy Medical Center - Sioux City
🇺🇸Sioux City, Iowa, United States
Hurley Medical Center
🇺🇸Flint, Michigan, United States
Cancer Center of Kansas, PA - El Dorado
🇺🇸El Dorado, Kansas, United States
Cancer Center of Kansas, PA - Liberal
🇺🇸Liberal, Kansas, United States
Hickman Cancer Center at Bixby Medical Center
🇺🇸Adrian, Michigan, United States
Bay Regional Medical Center
🇺🇸Bay City, Michigan, United States
Dickinson County Healthcare System
🇺🇸Iron Mountain, Michigan, United States
Mount Carmel Regional Cancer Center
🇺🇸Pittsburg, Kansas, United States
Caritas Norwood Hospital
🇺🇸Norwood, Massachusetts, United States
West Michigan Cancer Center
🇺🇸Kalamazoo, Michigan, United States
Bronson Methodist Hospital
🇺🇸Kalamazoo, Michigan, United States
Willmar Cancer Center at Rice Memorial Hospital
🇺🇸Willmar, Minnesota, United States
Regions Hospital Cancer Care Center
🇺🇸St. Paul, Minnesota, United States
HealthEast Cancer Care at St. John's Hospital
🇺🇸Maplewood, Minnesota, United States
Fairview Southdale Hospital
🇺🇸Edina, Minnesota, United States
Haematology-Oncology Associates of Ohio and Michigan, PC
🇺🇸Lambertville, Michigan, United States
Sparrow Regional Cancer Center
🇺🇸Lansing, Michigan, United States
Minnesota Oncology Hematology, PA - Woodbury
🇺🇸Woodbury, Minnesota, United States
Borgess Medical Center
🇺🇸Kalamazoo, Michigan, United States
Breslin Cancer Center at Ingham Regional Medical Center
🇺🇸Lansing, Michigan, United States
Cancer Center of Kansas, PA - Winfield
🇺🇸Winfield, Kansas, United States
Cotton-O'Neil Cancer Center
🇺🇸Topeka, Kansas, United States
St. Francis Comprehensive Cancer Center
🇺🇸Topeka, Kansas, United States
Cancer Center of Kansas, PA - Salina
🇺🇸Salina, Kansas, United States
Cancer Center of Kansas, PA - Wellington
🇺🇸Wellington, Kansas, United States
Cancer Resource Center at King's Daughters Medical Center
🇺🇸Ashland, Kentucky, United States
Louisiana State University Health Sciences Center - Monroe
🇺🇸Monroe, Louisiana, United States
Shawnee Mission Medical Center
🇺🇸Shawnee Mission, Kansas, United States
Saint Francis Medical Center
🇺🇸Cape Girardeau, Missouri, United States
Mercy and Unity Cancer Center at Mercy Hospital
🇺🇸Coon Rapids, Minnesota, United States
Miller - Dwan Medical Center
🇺🇸Duluth, Minnesota, United States
St. Joseph Mercy Oakland
🇺🇸Pontiac, Michigan, United States
Duluth Clinic Cancer Center - Duluth
🇺🇸Duluth, Minnesota, United States
St. Francis Cancer Center at St. Francis Medical Center
🇺🇸Shakopee, Minnesota, United States
Ridgeview Medical Center
🇺🇸Waconia, Minnesota, United States
William Beaumont Hospital - Royal Oak Campus
🇺🇸Royal Oak, Michigan, United States
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
🇺🇸Minneapolis, Minnesota, United States
St. Mary Mercy Hospital
🇺🇸Livonia, Michigan, United States
St. John's Regional Health Center
🇺🇸Springfield, Missouri, United States
Minnesota Oncology Hematology, PA - Maplewood
🇺🇸Maplewood, Minnesota, United States
Mercy Regional Cancer Center at Mercy Hospital
🇺🇸Port Huron, Michigan, United States
United Hospital
🇺🇸Saint Paul, Minnesota, United States
Billings Clinic - Downtown
🇺🇸Billings, Montana, United States
Northern Montana Hospital
🇺🇸Havre, Montana, United States
St. James Healthcare Cancer Care
🇺🇸Butte, Montana, United States
Big Sky Oncology
🇺🇸Great Falls, Montana, United States
Great Falls Clinic - Main Facility
🇺🇸Great Falls, Montana, United States
Glacier Oncology, PLLC
🇺🇸Kalispell, Montana, United States
Kalispell Medical Oncology at KRMC
🇺🇸Kalispell, Montana, United States
Sletten Cancer Institute at Benefis Healthcare
🇺🇸Great Falls, Montana, United States
St. Peter's Hospital
🇺🇸Helena, Montana, United States
CCOP - North Shore University Hospital
🇺🇸Manhasset, New York, United States
Methodist Estabrook Cancer Center
🇺🇸Omaha, Nebraska, United States
Elliot Regional Cancer Center at Elliot Hospital
🇺🇸Manchester, New Hampshire, United States
Beth Israel Medical Center - Petrie Division
🇺🇸New York, New York, United States
Guardian Oncology and Center for Wellness
🇺🇸Missoula, Montana, United States
Montana Cancer Specialists at Montana Cancer Center
🇺🇸Missoula, Montana, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
🇺🇸Missoula, Montana, United States
Don Monti Comprehensive Cancer Center at North Shore University Hospital
🇺🇸Manhasset, New York, United States
New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
🇺🇸Concord, New Hampshire, United States
Roswell Park Cancer Institute
🇺🇸Buffalo, New York, United States
St. Luke's - Roosevelt Hospital Center - St.Luke's Division
🇺🇸New York, New York, United States
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
🇺🇸New York, New York, United States
Winthrop University Hospital
🇺🇸Mineola, New York, United States
New Hampshire Oncology - Hematology, PA - Hooksett
🇺🇸Hooksett, New Hampshire, United States
Saint Peter's University Hospital
🇺🇸New Brunswick, New Jersey, United States
Lakes Region General Hospital
🇺🇸Laconia, New Hampshire, United States
Presbyterian Cancer Center at Presbyterian Hospital
🇺🇸Charlotte, North Carolina, United States
Mission Hospitals - Memorial Campus
🇺🇸Asheville, North Carolina, United States
High Point Regional Hospital
🇺🇸High Point, North Carolina, United States
Bismarck Cancer Center
🇺🇸Bismarck, North Dakota, United States
Grant Medical Center Cancer Care
🇺🇸Columbus, Ohio, United States
Trinity CancerCare Center
🇺🇸Minot, North Dakota, United States
Aultman Cancer Center at Aultman Hospital
🇺🇸Canton, Ohio, United States
St. Alexius Medical Center Cancer Center
🇺🇸Bismarck, North Dakota, United States
Barberton Citizens Hospital
🇺🇸Barberton, Ohio, United States
Summa Center for Cancer Care at Akron City Hospital
🇺🇸Akron, Ohio, United States
Mid Dakota Clinic, PC
🇺🇸Bismarck, North Dakota, United States
Mary Rutan Hospital
🇺🇸Bellefontaine, Ohio, United States
Wood County Oncology Center
🇺🇸Bowling Green, Ohio, United States
Community Cancer Center
🇺🇸Elyria, Ohio, United States
CCOP - Columbus
🇺🇸Columbus, Ohio, United States
Bethesda North Hospital
🇺🇸Cincinnati, Ohio, United States
Riverside Methodist Hospital Cancer Care
🇺🇸Columbus, Ohio, United States
Mercy Cancer Center at Mercy Medical Center
🇺🇸Canton, Ohio, United States
Adena Regional Medical Center
🇺🇸Chillicothe, Ohio, United States
Grady Memorial Hospital
🇺🇸Delaware, Ohio, United States
North Coast Cancer Care - Clyde
🇺🇸Clyde, Ohio, United States
Hematology Oncology Center
🇺🇸Elyria, Ohio, United States
Middletown Regional Hospital
🇺🇸Franklin, Ohio, United States
Blanchard Valley Medical Associates
🇺🇸Findlay, Ohio, United States
Knox Community Hospital
🇺🇸Mount Vernon, Ohio, United States
Licking Memorial Cancer Care Program at Licking Memorial Hospital
🇺🇸Newark, Ohio, United States
Fairfield Medical Center
🇺🇸Lancaster, Ohio, United States
Wayne Hospital
🇺🇸Greenville, Ohio, United States
St. Charles Mercy Hospital
🇺🇸Oregon, Ohio, United States
Charles F. Kettering Memorial Hospital
🇺🇸Kettering, Ohio, United States
Northwest Ohio Oncology Center
🇺🇸Maumee, Ohio, United States
St. Rita's Medical Center
🇺🇸Lima, Ohio, United States
Flower Hospital Cancer Center
🇺🇸Sylvania, Ohio, United States
Community Hospital of Springfield and Clark County
🇺🇸Springfield, Ohio, United States
Medical University of Ohio Cancer Center
🇺🇸Toledo, Ohio, United States
North Coast Cancer Care, Incorporated
🇺🇸Sandusky, Ohio, United States
Cancer Care Center, Incorporated
🇺🇸Salem, Ohio, United States
Toledo Clinic - Oregon
🇺🇸Oregon, Ohio, United States
Mercy Hospital of Tiffin
🇺🇸Tiffin, Ohio, United States
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
🇺🇸Allentown, Pennsylvania, United States
Willamette Falls Hospital
🇺🇸Oregon City, Oregon, United States
Toledo Hospital
🇺🇸Toledo, Ohio, United States
St. Vincent Mercy Medical Center
🇺🇸Toledo, Ohio, United States
Toledo Clinic, Incorporated - Main Clinic
🇺🇸Toledo, Ohio, United States
CCOP - Toledo Community Hospital
🇺🇸Toledo, Ohio, United States
St. Anne Mercy Hospital
🇺🇸Toledo, Ohio, United States
Fulton County Health Center
🇺🇸Wauseon, Ohio, United States
Cancer Treatment Center
🇺🇸Wooster, Ohio, United States
Mount Carmel St. Ann's Cancer Center
🇺🇸Westerville, Ohio, United States
Genesis - Good Samaritan Hospital
🇺🇸Zanesville, Ohio, United States
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
🇺🇸Xenia, Ohio, United States
Providence Milwaukie Hospital
🇺🇸Milwaukie, Oregon, United States
United States Air Force Medical Center - Wright-Patterson
🇺🇸Wright-Patterson Afb, Ohio, United States
Clackamas Radiation Oncology Center
🇺🇸Clackamas, Oregon, United States
Providence Newberg Medical Center
🇺🇸Newberg, Oregon, United States
Cancer Centers of the Carolinas - Easley
🇺🇸Easley, South Carolina, United States
Bon Secours St. Francis Health System
🇺🇸Greenville, South Carolina, United States
Cancer Centers of the Carolinas - Faris Road
🇺🇸Greenville, South Carolina, United States
AnMed Cancer Center
🇺🇸Anderson, South Carolina, United States
Self Regional Cancer Center at Self Regional Medical Center
🇺🇸Greenwood, South Carolina, United States
CCOP - Upstate Carolina
🇺🇸Spartanburg, South Carolina, United States
Cancer Centers of the Carolinas - Greer Medical Oncology
🇺🇸Greer, South Carolina, United States
Cancer Centers of the Carolinas - Seneca
🇺🇸Seneca, South Carolina, United States
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
🇺🇸Spartanburg, South Carolina, United States
Cancer Centers of the Carolinas - Spartanburg
🇺🇸Spartanburg, South Carolina, United States
LDS Hospital
🇺🇸Salt Lake City, Utah, United States
Medical X-Ray Center, PC
🇺🇸Sioux Falls, South Dakota, United States
U.T. Medical Center Cancer Institute
🇺🇸Knoxville, Tennessee, United States
Sanford Cancer Center at Sanford USD Medical Center
🇺🇸Sioux Falls, South Dakota, United States
Thompson Cancer Survival Center
🇺🇸Knoxville, Tennessee, United States
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
🇺🇸Murray, Utah, United States
Logan Regional Hospital
🇺🇸Logan, Utah, United States
Dixie Regional Medical Center - East Campus
🇺🇸Saint George, Utah, United States
H. Clay Evans Johnson Cancer Center at Memorial Hospital
🇺🇸Chattanooga, Tennessee, United States
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
🇺🇸Ogden, Utah, United States
Utah Valley Regional Medical Center - Provo
🇺🇸Provo, Utah, United States
Sandra L. Maxwell Cancer Center
🇺🇸Cedar City, Utah, United States
American Fork Hospital
🇺🇸American Fork, Utah, United States
Mountainview Medical
🇺🇸Berlin, Vermont, United States
Olympic Hematology and Oncology
🇺🇸Bremerton, Washington, United States
Fredericksburg Oncology, Incorporated
🇺🇸Fredericksburg, Virginia, United States
Columbia Basin Hematology
🇺🇸Kennewick, Washington, United States
Providence Centralia Hospital
🇺🇸Centralia, Washington, United States
Skagit Valley Hospital Cancer Care Center
🇺🇸Mt. Vernon, Washington, United States
Harborview Medical Center
🇺🇸Seattle, Washington, United States
Minor and James Medical, PLLC
🇺🇸Seattle, Washington, United States
Fred Hutchinson Cancer Research Center
🇺🇸Seattle, Washington, United States
Evergreen Hematology and Oncology, PS
🇺🇸Spokane, Washington, United States
CCOP - Northwest
🇺🇸Tacoma, Washington, United States
MultiCare Regional Cancer Center at Tacoma General Hospital
🇺🇸Tacoma, Washington, United States
St. Clare Hospital
🇺🇸Tacoma, Washington, United States
Southwest Washington Medical Center Cancer Center
🇺🇸Vancouver, Washington, United States
Green Bay Oncology, Limited at St. Mary's Hospital
🇺🇸Green Bay, Wisconsin, United States
St. Vincent Hospital Regional Cancer Center
🇺🇸Green Bay, Wisconsin, United States
Marshfield Clinic - Marshfield Center
🇺🇸Marshfield, Wisconsin, United States
Veterans Affairs Medical Center - Milwaukee
🇺🇸Milwaukee, Wisconsin, United States
All Saints Cancer Center at Wheaton Franciscan Healthcare
🇺🇸Racine, Wisconsin, United States
Ministry Medical Group at Saint Mary's Hospital
🇺🇸Rhinelander, Wisconsin, United States
Marshfield Clinic at Saint Michael's Hospital
🇺🇸Stevens Point, Wisconsin, United States
Saint Michael's Hospital Cancer Center
🇺🇸Stevens Point, Wisconsin, United States
Welch Cancer Center at Sheridan Memorial Hospital
🇺🇸Sheridan, Wyoming, United States
Rocky Mountain Oncology
🇺🇸Casper, Wyoming, United States
Kaiser Permanente Medical Center - Sacramento
🇺🇸Sacramento, California, United States
University of California Davis Cancer Center
🇺🇸Sacramento, California, United States
Mercy General Hospital
🇺🇸Sacramento, California, United States
Saint Joseph Mercy Cancer Center
🇺🇸Ann Arbor, Michigan, United States
CCOP - Michigan Cancer Research Consortium
🇺🇸Ann Arbor, Michigan, United States
Bozeman Deaconess Cancer Center
🇺🇸Bozeman, Montana, United States
St. Francis Hospital and Health Centers - Beech Grove Campus
🇺🇸Beech Grove, Indiana, United States
University Cancer Center at University of Washington Medical Center
🇺🇸Seattle, Washington, United States
Mercy and Unity Cancer Center at Unity Hospital
🇺🇸Fridley, Minnesota, United States
UVMC Cancer Care Center at Upper Valley Medical Center
🇺🇸Troy, Ohio, United States
St. Luke's Regional Medical Center
🇺🇸Sioux City, Iowa, United States
Caritas St. Elizabeth's Medical Center
🇺🇸Brighton, Massachusetts, United States
Sturdy Memorial Hospital
🇺🇸Attleboro, Massachusetts, United States
Wayne Memorial Hospital, Incorporated
🇺🇸Goldsboro, North Carolina, United States
Saint Joseph's Hospital
🇺🇸Marshfield, Wisconsin, United States
Kennestone Cancer Center at Wellstar Kennestone Hospital
🇺🇸Marietta, Georgia, United States
Doctors Hospital at Ohio Health
🇺🇸Columbus, Ohio, United States
Ingalls Cancer Care Center at Ingalls Memorial Hospital
🇺🇸Harvey, Illinois, United States
Providence St. Peter Hospital Regional Cancer Center
🇺🇸Olympia, Washington, United States
Long Island Jewish Medical Center
🇺🇸New Hyde Park, New York, United States
Marshfield Clinic - Wisconsin Rapids Center
🇺🇸Wisconsin Rapids, Wisconsin, United States
Bloomington Hospital Regional Cancer Institute
🇺🇸Bloomington, Indiana, United States
Comprehensive Cancer Care, PC
🇺🇸Saint Louis, Missouri, United States
St. John Macomb Hospital
🇺🇸Warren, Michigan, United States
Madigan Army Medical Center - Tacoma
🇺🇸Tacoma, Washington, United States
M.D. Anderson Cancer Center at Orlando
🇺🇸Orlando, Florida, United States
Jewish Hospital
🇺🇸Louisville, Kentucky, United States
Truman Medical Center - Hospital Hill
🇺🇸Kansas City, Missouri, United States
Saint Luke's Cancer Institute at Saint Luke's Hospital
🇺🇸Kansas City, Missouri, United States
St. Joseph Medical Center
🇺🇸Kansas City, Missouri, United States
North Kansas City Hospital
🇺🇸Kansas City, Missouri, United States
Heartland Hematology Oncology Associates, Incorporated
🇺🇸Kansas City, Missouri, United States
CCOP - Kansas City
🇺🇸Kansas City, Missouri, United States
Research Medical Center
🇺🇸Kansas City, Missouri, United States
Kaiser Permanente - Moanalua Medical Center and Clinic
🇺🇸Honolulu, Hawaii, United States
Tripler Army Medical Center
🇺🇸Honolulu, Hawaii, United States
Associates in Womens Health, PA - North Review
🇺🇸Wichita, Kansas, United States
Cancer Center of Kansas, PA - Medical Arts Tower
🇺🇸Wichita, Kansas, United States
Cancer Center of Kansas, PA - Wichita
🇺🇸Wichita, Kansas, United States
CCOP - Wichita
🇺🇸Wichita, Kansas, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
🇺🇸Wichita, Kansas, United States
Highland Hospital of Rochester
🇺🇸Rochester, New York, United States
Lipson Cancer and Blood Center at Rochester General Hospital
🇺🇸Rochester, New York, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
🇺🇸Rochester, New York, United States
Grandview Hospital
🇺🇸Dayton, Ohio, United States
Good Samaritan Hospital
🇺🇸Dayton, Ohio, United States
David L. Rike Cancer Center at Miami Valley Hospital
🇺🇸Dayton, Ohio, United States
Samaritan North Cancer Care Center
🇺🇸Dayton, Ohio, United States
CCOP - Dayton
🇺🇸Dayton, Ohio, United States
CCOP - Montana Cancer Consortium
🇺🇸Billings, Montana, United States
Northern Rockies Radiation Oncology Center
🇺🇸Billings, Montana, United States
St. Vincent Healthcare Cancer Care Services
🇺🇸Billings, Montana, United States
Lima Memorial Hospital
🇺🇸Lima, Ohio, United States
Strecker Cancer Center at Marietta Memorial Hospital
🇺🇸Marietta, Ohio, United States
Hutchinson Area Health Care
🇺🇸Hutchinson, Minnesota, United States