Effects of probiotic yogurt ingestion on inflammation and intestinal function in patients with inflammatory bowel disease

Not Applicable

Completed

Conditions: Condition 1: Inflammatory bowel disease. Condition 2: Inflammatory bowel disease.
Ulcerative colitis
Crohn's disease

Registration Number: IRCT201105106431N1

Lead Sponsor: Vice Chancellor for Research and Technology, Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 210

Inclusion Criteria

1- Ulcerative colitis or crohn's disease patients; 2- No history of using probiotic and prebiotic supplements within last 3 months; 3- No history of using antioxidant vitamin supplements within last 3 months; 4- No history of using omega-3 fatty acids supplements within last 3 months; 5- No history of using antibiotic drugs within last 3 months; 6- No history of other inflammatory diseases like rheumatoid arthritis and infectious disease; 7- No history of other gastrointestinal disease; 8- Body mass index(BMI) between 18.5 and 30; 9- No pregnancy and lactating stage in women; 10- Interested in participation and complete consent form. Exclusion criteria: 1-Not interested to continue the study; 2-Need for change drug's doses or types during the study.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
IL-1beta. Timepoint: At baseline and at the end. Method of measurement: ELISA commercial kits.;TNF-alpha. Timepoint: At baseline and at the end. Method of measurement: ELISA commercial kits.;Intestinal microflora. Timepoint: At baseline and at the end. Method of measurement: Real-time PCR.;Intestinal permability. Timepoint: At baseline and at the end. Method of measurement: HPLC.;IL-6. Timepoint: at baseline and at the end. Method of measurement: ELISA commercial kits.;CRP. Timepoint: At baseline and at the end. Method of measurement: ELISA commercial kits.;IL-10. Timepoint: At baseline and at the end. Method of measurement: ELISA commercial kits.

Secondary Outcome Measures

Name	Time	Method
Dietary intake of different fatty acids. Timepoint: At baseline and at the end. Method of measurement: Nutritionist IV, a software program.;Dietary intake of energy. Timepoint: At baseline and at the end. Method of measurement: Nutritionist IV, a software program.;Dietary intake of macronutrient. Timepoint: At baseline and at the end. Method of measurement: Nutritionist IV, a software program.;Dietary intake of cholestrol. Timepoint: At baseline and at the end. Method of measurement: Nutritionist IV, a software program.;Dietary intake of antioxidant vitamins. Timepoint: At baseline and at the end. Method of measurement: Nutritionist IV, a software program.;Dietary intake of fiber. Timepoint: At baseline and at the end. Method of measurement: Nutritionist IV, a software program.;Dietary intake of calcium. Timepoint: At baseline and at the end. Method of measurement: Nutritionist IV, a software program.