outcomes of two protocols of antibiotic prophylaxis in patients with positive urine culture undergoing percutaneous nephrolithotomy

Not Applicable

Conditions: Health Condition 1: N200- Calculus of kidney

Registration Number: CTRI/2020/04/024800

Lead Sponsor: Hardikkumar Hasmukhbhai Patel

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

All patients with renal calculus with age 18 to 70 years who are undergoing PC

Exclusion Criteria

Patient younger than eighteen years of age.

Presence of active urinary tract infection

Antibiotic use within last month for other causes

Patient with a stent, nephrostomy tube or indwelling catheter

Patient with stricture disease

Patient with benign prostatic hypertrophy (Prostate size > 40 gm )

Patient with Solitary kidney

Uncontrolled Diabetes mellitus

Patient with chronic kidney disease ( GFR < 60 ml/min)

Patient on immunosuppression treatment

Pus aspirated on initial percutaneous puncture

Patients with intraoperative complications during the procedure including bleeding leading to hypotension ,pulmonary complications like pneumothorax or hydrothorax

Patients with post-operative bleeding needing angioembolization

Patients with postoperative pulmonary complications like pneumothorax or hydrothorax.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the incidence of post-operative SIRS in patients with positive urine culture undergoing PCNL who have received two different protocols of antibiotic prophylaxis at 18months.Timepoint: To compare the incidence of post-operative SIRS in patients with positive urine culture undergoing PCNL who have received two different protocols of antibiotic prophylaxis at 18months.

Secondary Outcome Measures

Name	Time	Method
To compare the incidence of post-operative SIRS in patients with positive and negative urine culture undergoing PCNL <br/ ><br>To frame a departmental policy for surgical prophylaxis in patients undergoing PCNL with positive urine culture <br/ ><br>To find predictive factors for post-operative systemic inflammatory response syndrome (SIRS) in patients undergoing PCNL in our centre.Timepoint: 18months