A Randomized Controlled Trial Comparing 7 day Vonoprazan based Triple Therapy and 14 day Omeprazole based Triple Therapy for Helicobacter pylori Infectio
Phase 4
- Conditions
- Helicobacter pylori infection
- Registration Number
- TCTR20210219007
- Lead Sponsor
- Research department, Rajavithi hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Enrolling by invitation
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
1.Present with Helicobacter pylori infection: confirm by one or more of the following methods
-Urea breath test
-Rapid urea test or
- Histology
2. Patient agree to joint the project
Exclusion Criteria
1.history of allergy to PPI, vonoprazan, penicillin , clarithromycin
2. Previous H. Pylori eradication therapy
3. History of antibiotic to effect H. Pylori treatment before 1 month
4. History of GI malignancy or surgery
5. Serious cardiovascular, pulmonary, renal, hepatic disorder or malignancy
6. Pregnancy or lactating
7. History of drug or alcohol abuse
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Eradication rate of H. Pylori infection 4-6 week Eradication success was evaluated by 14C-urea breath test at 4-6 weeks after the completion of treatment
- Secondary Outcome Measures
Name Time Method Adverse event of H. Pylori treatment 3 and 14 days adverse reactions listed in the questionnaires were bitter taste, nausea and vomiting, diarrhea, and fatigue