The role of dopamine and noradrenaline in probability and reward value processing.
Completed
- Conditions
- De medicatie wordt gebruikt om het effect hiervan te bestuderen op de verwerking van subjectieve waardevolheid en waarschijnlijkheid in het brein.Medication will be used to study the effect on subjective value and probability processing in the brain.
- Registration Number
- NL-OMON44020
- Lead Sponsor
- niversiteit Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 36
Inclusion Criteria
Male, non-smoking, age between 18-45 years and passing the screening (assessing medical history and blood pressure/heart rate)
Exclusion Criteria
Psychopathology, current medication use, (history of) serious medical condition(s), low blood pressure
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Medication sessions:<br /><br>- Cue specific P200 ERP relative to no cue<br /><br>- Cue specific P300 ERP relative to no cue<br /><br><br /><br>Independent variable: dopaminergic antagonism by haloperidol and noradrenergic<br /><br>antagonism by clonidine.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Reaction times, percentage omissions and percentage correct responses<br /><br>Independent variable: dopaminergic antagonism by haloperidol and noradrenergic<br /><br>antagonism by clonidine.<br /><br>- Velocity scaling, which will measure bradykinesia<br /><br>- Spontaneous motor activity measurement, by using an actigraph<br /><br>- Event related potentials in response to the target<br /><br>- Questionnaire scores (BIS, BAS, ACS, STAI, POMS)<br /><br>- Low frequent resting state EEG activity</p><br>