Effects of brewed tea of poulk in rheumatoid arthritis
- Conditions
- Rheumatoid Arthritis.Rheumatoid arthritis, unspecified
- Registration Number
- IRCT2015032011335N5
- Lead Sponsor
- Connective Tissue Diseases Research Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 42
Subjects diagnosed with rheumatoid arthritis based on American College of Rheumatology and European League Against Rheumatism (ACR-EULAR) 2010 criteria for RA; Desire to attend in the study and signing the informed consent form; Desire to fill in the questionnaires and participate in sampling; Age range of 30 to 65 years; Being diagnosed with active rheumatoid arthritis (disease activity score-28 more than 3.2); Not receiving antioxidant or anti-inflammatory supplements since one month prior to the study
Exclusion criteria: Pregnancy; Lactation; Presence or history of other kinds of diseases and cancers; Other acute or chronic inflammatory diseases (such as colitis, psoriasis); AIDS; Sepsis; Type 2 diabetes mellitus; Thyroid disorders; Having side effects with poulk consumption besides drug side effects; Severe obesity (body mass index more than 40); Taking antioxidant supplements during the study; Smoking or being a passive smoker; Changing diet, physical activity and lifestyle during the study period; Unwillingness to continue the study
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical Outcomes (disease activity score in 28 joints). Timepoint: Before and after the 8-week intervention. Method of measurement: Using validated questionnaire.;Serum levels of inflammatory factors (intelukin-1, tumor necrosis factor-alpha, high sensitive-c reactive protein). Timepoint: Before and after the 8-week intervention. Method of measurement: Using commercially available kits and ELISA method.;Serum levels of matrix metalloproteinases: matrix metalloproteinase-1 and matrix metalloproteinase-3. Timepoint: Before and after the 8-week intervention. Method of measurement: Using commercially available kits and ELISA method.
- Secondary Outcome Measures
Name Time Method Dietary intake of energy and nutrients. Timepoint: Before and after the 8-week intervention. Method of measurement: Using 3-day dietary record.;Anthropometric parameters (height, weight, body mass index, waist and hip circumferences). Timepoint: Before and after the 8-week intervention. Method of measurement: Body weight is measured using a calibrated scale (Seca, Germany) to the nearest 0.5 kilogram. Standing height without shoes and circumferences of waist and hip are measured using a non-stretchable tape (Seca) to the nearest 0.5 centimeters. Body mass index is calculated through dividing weight (kilogram) by the height squared (meters).