Rehabilitation in MS: Influence of High Intensity Exercise on Insulin Resistance, Muscle Contractile Properties, Aerobic Capacity and Body Composition in Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- insulin sensitivity (insulin profile)
研究概览
简要总结
The purpose of this study is to investigate the effects of a combined training programme and a high intensity interval training programme on insulin resistance, muscle strength/ muscle contractile properties, aerobic capacity and body composition in MS patients.
It is assumed that the the above mentioned clinical parameters will improve due to physical exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosed MS according to the McDonald criteria
- •Expanded Disability Status Scale (EDSS) between 0.5 and 6
- •Be able to train 5 times in 2 weeks at the University
排除标准
- •Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases (like diabetes type 2)
- •Having had an relapse in a period of 3 months prior to the start of the intervention period
- •Having an relapse during the intervention period
- •Pregnancy and other contra indications for physical activity
- •Mental disorders
结局指标
主要结局
insulin sensitivity (insulin profile)
时间窗: change from baseline to 12 weeks
glucose and insulin concentration measurements in blood
muscle contractile properties
时间窗: from baseline to 12 weeks
measurements of cross sectional area and fiber distribution in muscle fibers of the m. vastus lateralis + measurements of enzymatic reactions, ATP, glycogen, ...
次要结局
- muscle strength of knee extensor/flexor(change from baseline to 12 weeks)
- body composition(Change from baseline to 12 weeks)
- aerobic capacity(change from baseline to 12 weeks)
- cytokine profile(change from baseline to 12 weeks)
- Self-reported measures(Change from baseline to 12 weeks)
研究者
Bert Op't Eijnde
Ph.D
Hasselt University