CHANCE - Candesartan in Hypertrophic Cardiomyopathy

Phase 2

• Conditions: Hypertrophic Cardiomyopathy

• Registration Number: NCT00430833
• Lead Sponsor: Charles University, Czech Republic

Brief Summary

The primary hypothesis of the study is that treatment with AT1-R antagonist in patients with nonobstructive form of HCM will be first save, second will cause regression of myocardial hypertrophy.

Detailed Description

Patients will be randomly assigned in 1:1 ratio either to candesartan (target dose 32 mg once daily) or matching placebo. The initial dose of the study drug will be 8 mg once daily. Study drug dose will be then doubled as tolerated every 2 weeks while aiming for a target dose of 32 mg once daily. Monitoring of blood pressure, serum creatinine, serum potassium and pressure gradient in LV outflow tract will be performed during dose increase. Patients will be observed clinically at 3, 6, and 12 months after the maintenance dose was reached. Exercise tolerance will be assessed by bicycle ergometry, presence of malignant arrhythmias by Holter monitoring, extent of LV hypertrophy by 2-dimensional echocardiography, and LV outflow tract pressure gradient by Doppler echocardiography at baseline and 12-month follow-up.

Study Timeline

• Status Verified: 2007-01
• Study First Submitted: 2007-01-31
• Study First Submitted QC: 2007-01-31
• Last Update Submitted: 2007-01-31
• Study First Posted: 2007-02-02
• Last Update Posted: 2007-02-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• HCM defined on the basis of echocardiographic criteria showing a nondilated, hypertrophied left ventricle (any wall thickness > 15 mm) in the absence of known causes of LV hypertrophy hypertension or valvular disease

Exclusion Criteria

• Hypertrophic obstructive cardiomyopathy defined as presence of resting gradient in left ventricular outflow tract ³30 mmHg or in righ ventricular outflow tract ³15 mmHg at Doppler echocardiography;
• Atrial fibrillation;
• Treatment with ACE inhibitors or AT1-R antagonists any time in the past;
• Contraindications to AT1-R antagonists;
• Coronary artery disease, renal failure, hepatic disorders or serious intercurrent illness limiting survival; and
• Poor echocardiographic image quality.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Trial Locations

Locations (1)

Cardiocenter, Third Faculty of Medicine, Charles University; 🇨🇿 Prague, Czech Republic