Ultrasound Guided Erector Spinae Plane Block in Breast Cancer Surgery: Analgesia, Spread and Immunomodulation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Analgesia
- Sponsor
- Alexandria University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Analgesic efficacy of ESPB
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Prospective interventional study
Detailed Description
The aim of the present study is to evaluate the effect of US guided unilateral ESPB using different volumes of local anaesthetics on analgesic efficacy, dermatomal spread and immunomodulation in breast cancer surgery. The primary outcome is the analgesic efficacy of the different local anaesthetic volumes of ESPB. The secondary outcomes are the dermatomal dye spread and sensory coverage, immunomodulation and complications in breast cancer surgery. Immunomodulation will be assessed by measuring Natural killer cells cytotoxicity.
Investigators
Ahmed Mohamed Mohamed Rabah Abdella
Principal investigator
Alexandria University
Eligibility Criteria
Inclusion Criteria
- •ASA physical status 1 or 2 scheduled for mastectomy under the effect of General Anaesthesia
Exclusion Criteria
- •Patient refusal.
- •Allergy or contraindication to any of the studied medications or anaesthetic agents.
- •Chronic opioid analgesic use.
- •Morbid obesity (BMI ≥ 40 kg/m2).
- •Scoliosis or any vertebral anomalies or previous spinal surgeries.
- •Infection at the site of injection or any other contraindication for regional anaesthesia.
- •Duration of surgery more than 90 minutes.
- •Renal impairment.
Outcomes
Primary Outcomes
Analgesic efficacy of ESPB
Time Frame: Up to 24 postoperative hours
Analgesic efficacy of Erector Spinae plabe block by measuring visual analogue scale which ranges from 0 to 10. 0 indicates no pain and 10 indicates maximum imaginable pain
Secondary Outcomes
- Spread of the injected dye in Erector Spinae plane(Patients will be imaged 15 minutes after the block and before induction of general anaesthesia and surgery.)
- Dermatomal sensory coverage of ESPB(Assessment will be done bilaterally every 3 minutes for 15 minutes after ESPB.)