Clinical Evaluation of Insect Repellent and Insecticide Treated Nets Against Malaria, JE & Dengue in Rural Communities in Lao PDR
Trial Snapshot
- Phase
- Phase 3
- Enrollment
- 5,000
- Locations
- 1
- Primary Endpoint
- reduction in malaria incidence
Study Overview
Brief Summary
Rural communities involved in agriculture are often at highest risk of insect-borne diseases in Southeast (SE) Asia.
Skin-applied insect repellents may prove a useful means of reducing mosquito-borne diseases for those people working outdoors in high risk areas.
This trial is evaluating the use of insect repellent (20% diethyltoluamide) to reduce incidence of malaria, Japanese Encephalitis and Dengue. The investigators will recruit up to 1000 households from 100 villages in rural Laos. In each house the investigators shall recruit up to 5 individuals. Half of households will be randomised to repellent, half to a placebo. All individuals will be provided with insecticide treated bed nets for use at night. All household occupants will be followed for 7 months to record malaria cases by Rapid Diagnostic Test every month. Blood spots will be collected at start and end of study to measure Japanese Encephalitis and Dengue. All positive cases will be promptly treated. Outcome will be reduction in number of malaria cases (primary outcome) and Dengue/Japanese Encephalitis (secondary outcomes).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 5 Years to 70 Years (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •working in agriculture
- •available for monthly follow-up
Exclusion Criteria
- •allergy to repellent
- •pregnant / breastfeeding
Arms & Interventions
20% deet insect repellent
experimental intervention
Intervention: 20% deet insect repellent (Drug)
lotion without repellent active
Intervention: placebo control (Drug)
Outcomes
Primary Outcomes
reduction in malaria incidence
Time Frame: monthly over 7 months
Secondary Outcomes
- Reduction in Japanese Encephalitis and / or Dengue infections(After 7 months intervention)