The Causative Insects in Severe Insect Sting Allergy

Not Applicable

Completed

• Conditions: Insect Sting Allergy
• Interventions: Other: Skin prick test; Other: sIgE measurement

• Registration Number: NCT02764242
• Lead Sponsor: Mahidol University

Brief Summary

Study the causative insect by skin prick test and sIgE to wasp, bee and fire ants are important but false positive by crossreactivity can occur. sIgE to recombinant venom allergen is proposed to help in finding the causative insect.

Detailed Description

Insect sting allergy from insects in Hymenoptera is not uncommon. The reaction maybe very severe and life threatening. To find the cause of insect sting allergy is important in prevention and specific treatment such as immunotherapy. The skin prick test and sIgE of these insects may have cross reactions so it is difficult to be interpreted.

The usage of sIgE recombinant venom allergen can benefit in separate cross reaction and dual allergy reaction.

Basic Information
|
Recruitment & Eligibility
|
Study & Design

Study Timeline

• Study Start: 2015-02
• Primary Completion: 2016-03
• Study Completion: 2016-04
• Status Verified: 2016-05
• Study First Submitted: 2016-05-04
• Study First Submitted QC: 2016-05-04
• Last Update Submitted: 2016-05-04
• Study First Posted: 2016-05-06
• Last Update Posted: 2016-05-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Cases with severe insect sting allergy reactions

Read More

Exclusion Criteria

• Without other severe systemic diseases
• Not pregnant or lactation

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
insect sting allergy	sIgE measurement	Skin prick tests to local and imported insect sting allergen with different concentration are performed. sIgE Measurement (to insect and the recombinant venom)
insect sting allergy	Skin prick test	Skin prick tests to local and imported insect sting allergen with different concentration are performed. sIgE Measurement (to insect and the recombinant venom)

Primary Outcome Measures

Name	Time	Method
Mean wheal diameters of skin prick test of local and imported insect allergens	12 months	Compare Mean wheal diameters of skin prick test of local and imported insect allergens at different concentrations

Secondary Outcome Measures

Name	Time	Method
specific IgE level to stinging insect allergen and recombinant venom allergens	12 months	compare skin prick test result and levels of specific IgE level to stinging insect allergen and recombinant venom allergens