Clinical Evaluation of Insect Repellent and Insecticide Treated Nets Against Malaria, JE & Dengue in Rural Communities in Lao PDR
试验速览
- 阶段
- 3 期
- 入组人数
- 5,000
- 试验地点
- 1
- 主要终点
- reduction in malaria incidence
研究概览
简要总结
Rural communities involved in agriculture are often at highest risk of insect-borne diseases in Southeast (SE) Asia.
Skin-applied insect repellents may prove a useful means of reducing mosquito-borne diseases for those people working outdoors in high risk areas.
This trial is evaluating the use of insect repellent (20% diethyltoluamide) to reduce incidence of malaria, Japanese Encephalitis and Dengue. The investigators will recruit up to 1000 households from 100 villages in rural Laos. In each house the investigators shall recruit up to 5 individuals. Half of households will be randomised to repellent, half to a placebo. All individuals will be provided with insecticide treated bed nets for use at night. All household occupants will be followed for 7 months to record malaria cases by Rapid Diagnostic Test every month. Blood spots will be collected at start and end of study to measure Japanese Encephalitis and Dengue. All positive cases will be promptly treated. Outcome will be reduction in number of malaria cases (primary outcome) and Dengue/Japanese Encephalitis (secondary outcomes).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 5 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •working in agriculture
- •available for monthly follow-up
排除标准
- •allergy to repellent
- •pregnant / breastfeeding
研究组 & 干预措施
20% deet insect repellent
experimental intervention
干预措施: 20% deet insect repellent (Drug)
lotion without repellent active
干预措施: placebo control (Drug)
结局指标
主要结局
reduction in malaria incidence
时间窗: monthly over 7 months
次要结局
- Reduction in Japanese Encephalitis and / or Dengue infections(After 7 months intervention)