OCTA and Retinal Angiomatous Proliferation
Completed
- Conditions
- Age Related Macular Degeneration
- Interventions
- Diagnostic Test: optical coherence tomography angiography
- Registration Number
- NCT04689789
- Lead Sponsor
- Federico II University
- Brief Summary
To investigate, using optical coherence tomography angiography, the retinal vascular features in patients affected by RAP.
- Detailed Description
Retinal vascular anomalous complex represents a distinct form of neovascularization in patients with age-related macular degeneration.
The study investigated the changes in retinal vascular network using optical coherence tomography angiography, a novel and non invasive diagnostic technique that allows to better understand the pathophysiologic mechanism of this neovascularization.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 118
Inclusion Criteria
- age older than 65 years
- diagnosis of retinal angiomatous proliferation and reticular pseudodrusen
- absence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
- absence of significant lens opacities, low-quality OCT-A images.
Exclusion Criteria
- age older than 80 years
- absence of diagnosis of retinal angiomatous proliferation and reticular pseudodrusen
- presence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
- presence of significant lens opacities, low-quality OCT-A images.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with RAP optical coherence tomography angiography Patients with previous diagnosis of retinal angiomatous proliferation Patients with reticular pseudodrusen optical coherence tomography angiography Patients with previous diagnosis of reticular pseudodrusen Control group optical coherence tomography angiography Healthy eyes without actual and previous ocular diseases
- Primary Outcome Measures
Name Time Method The measurements of retinal vascular network in patients with age-related macular degeneration, using optical coherence tomography angiography, compared to controls 15 months The parameters analyzed by optical coherence tomography angiography were: vessel density of superficial capillary plexus and deep capillary plexus
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Federico II University
🇮🇹Naples, Napoli, Italy