A comparative study of intravenous magnesium sulphate and nebulization of magnesium sulphate on attenuation of intubation response and airway pressure in patients undergoing laparoscopic surgeries, a randomized control trial.
Trial Snapshot
- Phase
- Phase 2
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 96
- Locations
- 1
- Primary Endpoint
- To compare hemodynamic response after intubation.
Study Overview
Brief Summary
Endotracheal intubation is an important component of general anesthesia. Laryngoscopy causes stimulation of sympathetic nervous system and causes increase in concentration of catecholamines like adrenaline and noradrenaline. This can cause left ventricular failure, renal failure, surgical bleeding, cerebral hemorrhage and myocardial ischemia in patients with general anesthesia. Various drugs like Magnesium sulphate , lidocaine, dexmedetomidine can be used in attenuating response to intubation.
The current Randomized controlled trial is carried out to compare attenuation response of magnesium sulphate in two different route of administration i.e, intravenous and nebulization as studies comparing them are scarce.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Participant, Investigator and Outcome Assessor Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients aged between 18 to 60 years .
- •Patients willing to give informed written consent Patients with ASA Grade 1 and Grade 2 Patients scheduled for surgeries under general anaesthesia for laparoscopy.
Exclusion Criteria
- •Patients refusal to give informed written consent Patients belonging to ASA Grade 3, 4, 5 Patients with cardiovascular, respiratory, renal and hepatic derangement Patients with history of drug allergy Pregnant women Patients with anticipated difficult airway.
Outcomes
Primary Outcomes
To compare hemodynamic response after intubation.
Time Frame: AT Basal, 2min, 5 min and 7 min after intubation
Secondary Outcomes
- To compare peak airway pressures after intubation.(At Basal , 2 min , 5 min, 7 min after intubation)
Investigators
Dr Sathya H
Bangalore Medical College and Research institute, Bangalore