A clinical study to examine the effects of dexmedetomidine given intravenously to patients undergoing spinal anesthesia for lower limb surgeries.
Not Applicable
Completed
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2021/08/035368
- Lead Sponsor
- KPC Medical College and Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Patients of American Society of Anesthesiologists(ASA) Grades I and II.
Patients undergoing elective lower limb surgery with spinal anesthesia.
Exclusion Criteria
Patients outside age group of 18-65 years.
Patients allergic to dexmedetomidine.
Patients of ASA Grades III, IV, V, VI.
Significant cardiovascular, pulmonary, hepatic or renal impairment.
Pregnant patients.
Obese patients (BMI more than 30 kg/m2).
Patients on �²-blocker and Ca2+ channel blocker.
Contraindications for regional anesthesia including coagulopathy, or local skin infection.
Patients preferring general anesthesia.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Onset of block including autonomic, sensory and motor block <br/ ><br>Duration of block <br/ ><br>Perioperative hemodynamic adverse effects <br/ ><br>Timepoint: Sensory blockade will be evaluated by two-dermatomal regression from the maximum level, and regression to S1 level will be noted at 1, 2, 5 min after giving spinal anesthesia and then at every 5 min till 30 min and then at every 15 min till recovery of block to S1 level. <br/ ><br>Motor blockade will be assessed by modified Bromage scale at 1, 2, and 5 min after giving spinal anesthesia, then at every 5 min till 30 min and then every 15 min till full recovery of motor level. <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method Sedation and post-operative analgesia by Visual Analogue ScaleTimepoint: Ramsay level of sedation scale will be used to assess sedation at 1, 2, and 5 min after giving spinal anesthesia, then at every 5 min till 30 min and then every 15 min till discharge from postanesthesia care unit. <br/ ><br>Postoperative pain intensity will be assessed using a 10-point visual analog scale (VAS) for 24 hours. <br/ ><br>Postoperative nausea, vomiting, and shivering will be observed till the discharge of the patient.