Effect of Dietary Supplementation With Omega-3 Fatty Acid on the Adaptive Muscular Response to Resistance Training in Sarcopenic Elderly Women
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change from Baseline muscle volume after 14 weeks
研究概览
简要总结
Both aging and other factors associated with it may contribute to the development of sarcopenia, such as lack of physical activity, inadequate food intake, hormonal changes and age-related increases in cytokine levels. What is a growing number of elderly people in Brazil and the world, it is extremely important to conduct research in order to know the mechanisms of action of new strategies to combat sarcopenia. Supplementation with omega-3 fatty acids is a promising intervention in sarcopenic rest. However, there is a practice of studies confirming the effects of omega-3 fatty acid supplementation on neuromuscular function in the elderly.
详细描述
The aim of this study is to investigate the effect of omega 3 polyunsaturated fatty acid supplementation on the muscular adaptive response in sarcopenic elderly women submitted to resistance training. A total of 30 sarcopenic elderly women, aged 65 years or older, were divided into two groups of 15 volunteers: (1) Exercise group and placebo (GEP) and (2) Exercise group and fish oil (GEOP). The two groups underwent a resisted exercise program over 12 weeks in three weekly sessions supervised by physicists and physicists at the School of Physical Education and Sports of Ribeirão Preto (EEFERP). All volunteers (both groups) are also instructed to ingest two food supplement capsules at each main meal, and the GEP group will use capsules composed of sunflower oil as a placebo. The GEOP is directed to take two capsules of fish oil at each main meal, totaling 4 capsules per day, that is, four grams of fish oil. To check the quadriceps muscle volume before and after an intervention, as volunteers from both groups are submitted to MRI. An extension power and isokinetic force of extension of the lower limb at a knee and hip extension and are measured by dynamometry (Biodex 4 Pro, Biodex, USA) and a functional solution evaluated by the application of the 6-minute walk test. In addition, will be described the biochemicals for the quantification of the following cytokines: IL1, IL6, IL8, IL10 and TNF-α, such as to allow selection of the presence of inflammation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 85 Years（Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Being sedentary (moderate to vigorous physical activity for at least 3 months)
- •BMI <30.00 kg / m2;
排除标准
- •Any type of absolute and / or relative contraindication to moderate or intense physical activity.
- •Any physical limitation that makes it impossible to practice physical activities and / or that impairs the performance of the tests.
- •Also not included are those volunteers who do not go through pre-Physical Activity evaluation. (Par Q Questionnaire)
- •miss more than 3 workouts consecutive
研究组 & 干预措施
Group exercise fish oil
Using the Randomizer Research program, 15 elderly women will participate in a resistance exercise protocol and receive omega-3 fatty acid supplements to be ingested 2g in the main meals, totaling 4g daily.
干预措施: Fish oil (Drug)
Group exercise placebo
Using the Randomizer Research program, 15 elderly women will participate in a resistance exercise protocol and receive sunflower oil to be ingested 2g in the main meals, totaling 4g daily.
干预措施: sunflower oil (Drug)
结局指标
主要结局
Change from Baseline muscle volume after 14 weeks
时间窗: before and after 14 weeks
Calculated by Nuclear Magnetic Resonance
Change from Baseline muscle strength of knee extensors after 14 weeks
时间窗: before and after 14 weeks
Measure of muscle strength of the lower limbs (knee extension) with a isokinetic dynamometer (Biodex 4 Pro)
次要结局
- Assessment of serum levels of inflammatory cytokines(before and after 14 weeks)
- Assessment of physical performance(before and after 14 weeks)
- Assessment of handgrip strength(before and after 14 weeks)
- Physical Activity behaviour(before and after 14 weeks)
研究者
Eduardo Ferriolli
Assistant professor
University of Sao Paulo