Omega-3 Fatty Acids and Nutritional Support in Gastrointestinal Cancer

Not Applicable

Recruiting

• Conditions: Sarcopenia
• Interventions: Dietary Supplement: Standard; Dietary Supplement: omega-3

• Registration Number: NCT06015971
• Lead Sponsor: Maimónides Biomedical Research Institute of Córdoba

Brief Summary

Sarcopenia is a frequent complication in patients with cancer and chronic diseases, it is characterized by decreased muscle strength and fatigue due to reduced skeletal muscle mass, which is accompanied by atrophy and decreased quality of muscle tissue. In all cases, it negatively impacts treatment tolerance, clinical outcomes and survival, in consequence, quality of life of these patients decreases while morbidity, mortality and costs increase. In this context, appropriate nutritional screening and early nutrition support are extremely recommended, to this aim, in some cases, oral nutritional supplements (ONS) are necessary; ONS could have a standard formula or be enriched with specific nutrients (arginine, glutamine, branched chain amino acids, n-3 fatty acids, and nucleotides), which can modulate the activity of the immune system and provide an additional benefit beyond the nutritional support, this intervention type is called immunonutrition. Despite these possible benefits, their utility has been proven in few clinical scenarios, for example in with patients with upper gastrointestinal cancer undergoing surgical resection; based on this, current guidelines recommend that patients should receive oral/enteral nutritional support with an specific formula enriched in immunonutrients (with arginine, n-3 fatty acids or nucleotides) , but there is a lack of evidence for supporting its use in other clinical conditions including patients with cancer that receive systemic treatment

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-01
• Study First Submitted: 2023-08-23
• Study First Submitted QC: 2023-08-23
• Study First Posted: 2023-08-29
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-05
• Last Update Posted: 2025-05-06
• Primary Completion: 2026-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• • Patients with Gastrointestinal tumor undergoing systemic treatment (chemo-radio-immuno therapy or their combination)
• Body weight loss >5% in the previous three months or >10% in the previous six months
• Both sexes
• Age between 18-85 y-old.

Exclusion Criteria

• Life expectancy < 2 weeks
• MDRD < 15 mL/min
• End-stage liver disease
• Any musculoskeletal, cardiovascular and/or neurological disorders that could affect exercising.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
standard hypercaloric, hyperproteic oral supplement	Standard	-
omega-3 enriched oral supplement	omega-3	-

Primary Outcome Measures

Name	Time	Method
Functionality	12 weeks	Changes in functionality measured with the Up and Go Test
Muscle mass	12 weeks	Muscle mass change (in Kg)

Secondary Outcome Measures

Name	Time	Method
Albumin	12 weeks	Changes in serum albumin levels (g/dl)
C-RP	12 weeks	Changes in serum C-RP(g/dl)

Trial Locations

Locations (1)

IMIBIC; 🇪🇸 Cordoba, Spain