Effects of Tradipitant on Satiation, Gastric Volume, Gastric Accommodation, and Gastric Emptying in Healthy Volunteers
- Registration Number
- NCT04849559
- Lead Sponsor
- Vanda Pharmaceuticals
- Brief Summary
To evaluate the effects of tradipitant relative to placebo on satiation, gastric volume, gastric accommodation, and gastric emptying in healthy volunteers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 27
Inclusion Criteria
- Able to provide written consent
- Body Mass Index (BMI) of 18-35 kg/m2
- No medical problems or chronic diseases
Exclusion Criteria
- Diagnosis of gastrointestinal diseases
- Structural or metabolic diseases that affect the GI system
- A positive test for drugs of abuse at screening
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Oral Capsule Tradipitant Tradipitant Oral Capsule
- Primary Outcome Measures
Name Time Method Fasting Gastric Volume as Measured by Single Photon Emission Computed Tomography (SPECT) 9 Days Fasting Gastric volume
Accommodation Volume as Measured by SPECT 9 Days Gastric Accommodation post 300mL Ensure
Satiation Expressed as Volume to Fullness as Measured by Satiation Test 9 Days Gastric Emptying Half-time of Solids as Measured by Scintigraphy 9 Days Gastric Emptying Solids, T50%, Min
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Vanda Investigational Site
🇺🇸Rochester, Minnesota, United States