Hypertensive treatment in elderly with cerebral small vessel disease: should we SPRINT faster?

Withdrawn

Conditions: Hypertension High Blood Pressure
10007963
10057166

Registration Number: NL-OMON47398

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

- * 65 years of age
- High systolic blood pressure of 150-200 mmHg assessed with a daytime 24-hour BP (with or without taking antihypertensive medication)
- Cerebral small vessel disease (white matter lesions; Fazekas score * 2) on MRI

Exclusion Criteria

- Diabetes mellitus
- Experienced myocardial infarction within the past 12 months
- Medical history of stroke in the past 6 months or large (sub) cortical cerebral infarction on MRI
- Medical history of end stage heart failure (NYHA III-IV)
- Stage 4-5 kidney failure
- Clinical Dementia Rating (CDR) scale>1
- Life expectancy less than 1 year
- Unable to obtain an optimal window for TCD measurements
- Significant stenosis (>70%) of the left of right common carotid artery

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome measures are: CBF (static and dynamic) velocity measured<br /><br>with Transcranial Doppler (TCD). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures are: cognitive functioning, degree of white matter<br /><br>lesions. orthostatic hypotension, cerebral autoregulatory capacity, CO2<br /><br>responsiveness, premature trial termination because of unacceptable drug side<br /><br>effects.</p><br>