CSF Cholinergic Biomarkers and Postoperative Cognitive Change
Completed
- Conditions
- Fracture of Lower LimbKnee OsteoarthritisNecrosis of Femoral Head
- Registration Number
- NCT02063542
- Lead Sponsor
- RenJi Hospital
- Brief Summary
Previous study demonstrated that the condition of central cholinergic nerve is important for the postoperative cognitive dysfunction. In present study investigators hypothesized that the acetylcholine concentration in the cerebral spinal fluid is associated to the postoperative cognitive changes in aged patients undergoing osteopathic surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 102
Inclusion Criteria
- Elder than 60 years old
- Spoke proficient Mandarin Chinese
- Agree to undergoing spinal plus general anesthesia
- Selected total knee replacement surgery
Exclusion Criteria
- Patients with neurological and/or psychiatric diseases, including AD, stroke and psychosis
- Have contraindication for spinal anesthesia such as clotting disorder local infection in the puncture site
- Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
- Several audition or vision disorder
- Unwillingness to comply with the protocol or procedures.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Short-term postoperative cognitive dysfunction rate The day before surgery and 7 days after surgery (or before leave hospital) Concentration of choline acetyltransferase in CSF During spinal anesthesia Concentration of Acetylcholine in CSF During spinal anesthesia Concentration of acetylcholinesterase in CSF During spinal anesthesia
- Secondary Outcome Measures
Name Time Method Long-term postoperative cognitive dysfunction rate Two months after surgery
Trial Locations
- Locations (1)
Renji hospital, School of Medicine, Shanghai Jiaotong University
🇨🇳Shanghai, Shanghai, China