Comparison of Intravenous Midazolam and Dexmedetomidine when given before operation in Laproscopic cholecystectomy with CNS monitoring with Propofol for induction of Anaesthesia.
Not Applicable
- Conditions
- Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis
- Registration Number
- CTRI/2022/09/045193
- Lead Sponsor
- Sharda Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patient scheduled for elective laproscopic cholecystectomy
2. age 18-60 years
3. both genders
4. ASA grade 1 and 2
Exclusion Criteria
1. Patients refusal to participate in study
2. Morbid obesity BMI >30
3. History of sleep apnoea
4. Pharmacological therapy - Benzodiazipines, opoids , antipsychotics
5. anticipated difficult intubation
6. Sinus bradycardia or bundle branch block on ECG
7. Pregnant females
8. coagulopathy or bleeding diathesis
9. history of hypertension , diabetes mellitus, thyroid disease.
10. history of CNS , cardiovascular and renal diesease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the induction dose of propofol , in the three groups , midazolam , dexmedetomidine and the control groupTimepoint: We will monitor Heart Rate, Blood Pressure, Oxygen saturation ,Bispectral Index Value at - <br/ ><br>Preoperative period <br/ ><br>Preinduction period <br/ ><br>Preintubation . <br/ ><br>At The Time of intubation. <br/ ><br>Post intubation every minute till 10 minutes then <br/ ><br>every 10 minute till the end of surgery <br/ ><br> then we will monitor the outcome with modified Aldrete score post operatively.
- Secondary Outcome Measures
Name Time Method 1. To compare the haemodynamic changes between different groups during intubation. <br/ ><br>2. To compare the recovery profile between different groups. <br/ ><br>3. To observe the post anaesthetic complications if any.Timepoint: 1 hour