Comparison of the Effect of Sevoflurane and Desflurane on Patient State Index: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- patient state index
研究概览
简要总结
The aim of this study is to compare the patient state index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent volatile anesthesia.
详细描述
There have been several studies comparing electroencephalogram-derived indices produced by sevoflurane and desflurane. However, to the best of our knowledge, there has been no study which compared the two inhaled anesthetics using patient state index. Therefore, the aim of this study is to compare the patient state index values produced by sevoflurane and desflurane at equi-MAC in patients undergoing single-agent inhalation anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients aged between 19 and 65 yr
- •patients with American Society of Anesthesiologists physical status classification I or II
- •patients scheduled for elective surgery under volatile anesthesia
- •patients obtaining written informed consent
排除标准
- •patients with a history of any psychiatric or neurological disease
- •patients receiving any medication affecting the autonomic or central nervous system
- •patients with a history of alcohol or drug abuse
- •pregnant or lactating women
研究组 & 干预措施
Sevoflurane
Anesthesia is maintained with sevoflurane.
干预措施: Sevoflurane (Drug)
Desflurane
Anesthesia is maintained with desflurane.
干预措施: Desflurane (Drug)
结局指标
主要结局
patient state index
时间窗: After a 30-min waiting period from the induction of anesthesia
patient state index value at a steady-state anesthesia of equi-MAC
次要结局
未报告次要终点
研究者
Kyoung-Ho Ryu, MD
Assistant professor
Kangbuk Samsung Hospital