Study to Improve Scientific Understanding of the Cardiovascular Actions of Cocaine
- Conditions
- Cocaine Induced Sympathoexciation and Vasoconstriction
- Registration Number
- NCT00338546
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Brief Summary
The purpose of this study is to improve the scientific understanding of the cardiovascular actions of cocaine, in particular the ability of cocaine to increase blood pressure.
- Detailed Description
Cocaine abuse has emerged as a major cause of life-threatening cardiovascular emergencies but our understanding of the underlying mechanisms mediating the adverse effects of cocaine is far from complete. Our previous studies in cocaine-naive human subjects have demonstrated that intranasal cocaine acutely stimulates the human cardiovascular system by a novel central mechanism of action.We are currently investigating a central sympatholytic drug,dexmedetomidine, in reversing the sympathomimetic effects (increase in blood pressure, heart rate and coronary vasoconstriction) of intranasal cocaine.This drug may be a new pharmacologic agent in the treatment of acute cocaine intoxication in humans.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- Cocaine naive healthy volunteers
- Any evidence of cardiopulmonary disease by history or physical examination
- History of hypertension or 24 hour blood pressure averaging >135/85 mmHg
- Any history of substance abuse (other than tobacco)
- Diabetes mellitus or other systemic illness
- Individuals with a history of pseudocholinesterase deficiency
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Skin sympathetic nerve activity Skin blood flow Coronary blood flow Blood pressure Heart rate
- Secondary Outcome Measures
Name Time Method Sedation status
Trial Locations
- Locations (1)
Univ of Texas Southwestern Medical Center
🇺🇸Dallas, Texas, United States