EVALUATION OF SALIVARY AND SERUM INTERLEUKIN -38 AND THROMBOMODULIN LEVELS IN PERIODONTITIS PATIENTS BEFORE AND AFTER NON-SURGICAL PERIODONTAL THERAPY: A CLINICAL AND BIOCHEMICAL STUDY
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 49
- 试验地点
- 1
- 主要终点
- Change in IL-38 and thrombomodulin concentrations (saliva and serum) — measured by ELISA.
研究概览
简要总结
Aim of the study is to evaluate the salivary and serum levels of Interleukin-38 (IL-38) and Thrombomodulin (TM) in patients with periodontitis before and after non-surgical periodontal therapy (NSPT). IL-38, a recently identified anti-inflammatory cytokine, and TM, an endothelial glycoprotein with anticoagulant activity, may play significant roles in periodontal inflammation and healing. By assessing 49 patients with Stage II periodontitis, clinical parameters such as plaque index, gingival bleeding index, probing depth, and attachment level, along with biochemical analysis of IL-38 and TM using ELISA, will be compared pre- and post-therapy. The study seeks to determine whether changes in these biomarkers reflect treatment outcomes, potentially establishing them as novel indicators for monitoring disease activity and therapeutic response in periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 21.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Age- 21 to 60 years of age Both males and females.
排除标准
- •Individuals with systemic illness
- •Pregnant & lactating women
- •History of medications such as antibiotics or anticoagulant therapy for past 6 months
- •Participants with previous periodontal treatment or periodontal surgery for past 6 months 5.
结局指标
主要结局
Change in IL-38 and thrombomodulin concentrations (saliva and serum) — measured by ELISA.
时间窗: Change in IL-38 and thrombomodulin concentrations (saliva and serum) — measured by ELISA.At baseline and 4 weeks after treatmnet
次要结局
- Clinical periodontal parameters (measured by calibrated examiner):(Mean probing depth (PD), mean clinical attachment level (CAL), and bleeding on probing (BOP %).)
研究者
Dr Supriti Brahma
Department of Periodontology, Room no- 106, SRM Kattankulathur Dental College