A Study to Evaluate the Effect of Genetic Variation on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetics
Phase 3
Recruiting
- Conditions
- Healthy
- Interventions
- Other: SalineBiological: Exendin-9,39
- Registration Number
- NCT04466566
- Lead Sponsor
- Adrian Vella
- Brief Summary
The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal. The purpose of this research study to find out how genetic variations in GLP1R alter insulin secretion, in the fasting state and when blood sugars levels are elevated.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- 40 nondiabetic subjects will be recruited.
- 20 subjects with the AA genotype at rs3765467 and remainder will have the GG genotype.
- Individuals encompassing the age span of 25-65 years.
Exclusion Criteria
- Individuals under 25 and over 65 years of age.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Saline Saline Saline will be infused during the study Exendin-9,39 Exendin-9,39 Exendin-9,39 will be infused during the study
- Primary Outcome Measures
Name Time Method Insulin secretion quantified using the minimal model to generate an index of beta-cell responsivity (Φ) This will be calculated from the 0-180 minute data of the study
- Secondary Outcome Measures
Name Time Method Glucagon secretion measured by immunoassay This will be averaged over the 0-180 minute data of the study
Trial Locations
- Locations (1)
Mayo Clinic in Rochester
🇺🇸Rochester, Minnesota, United States