Effect of heparin reversal by protamine sulfate on the outcome of thrombolysis in acute ischemic stroke after percutaneous coronary interventio
- Conditions
- Nervous System Diseases
- Registration Number
- PACTR202109714591017
- Lead Sponsor
- neurology department ain shams university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 60
1. Adults (~18 years or over) undergoing elective or emergency PCI.
2.Acute ischemic stroke, defined as focal neurological deficit occurring during or immediately after PCI, and diagnosed by an expert neurologist.
3.Stroke within 4 hours of onset.
4.National institutes of health stroke scale (NIHSS) ranging from 4-15.
5.NIHSS < 4 if causing strategic deficit (e.g.: aphasia).
6.CT brain is negative for hemorrhage.
7.Patients fulfilled the inclusion criteria for TPA.
8.All participants or their relatives give written consent for participation in this study.
1-Adolescents or children (<18 years).
2-Patients who develop intracranial hemorrhagic stroke.
3-Large ischemic stroke (NIH >15).
4-Mild neurological deficit (NIH <3) and no strategic deficit.
5-Stroke onset beyond 4.5 hours
6-Exclusion criteria for TPA
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The pre-defined primary efficacy outcome measure is the change in NIHSS score from baseline to 48hrs and on discharge . <br> ;The pre-defined primary safety measures are the rate of significant bleeding events and the rate of mortality during the hospital stay
- Secondary Outcome Measures
Name Time Method duration of hospital stay;secondary outcome measures were mRS on discharge and after 3months