Examining the Blood Sugar Response to Fruit Smoothie Consumption
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Glycaemic index of product with capillary vs CGM
研究概览
简要总结
Glycaemic responses to fruit smoothies may depend on the food matrix (e.g., degree of processing and physical structure), ingestion rate, dose ingested and fibre content. Furthermore, the method of sampling could alter inferences. The aim of this project is to characterise how these factors affect the glycaemic response to a commercially available fruit smoothie. Participants will ingest 7 different test drinks in a randomised, crossover design with fingerstick capillary blood sampling alongside continuous glucose monitors. Test drinks will include a glucose reference (CONTROL), the commercial product matched for carbohydrate to CONTROL (PRODUCT), equivalent carbohydrate ingested as whole fruits (WHOLE), equivalent carbohydrate ingested as blended fruits (WHOLE), equivalent carbohydrate as the commercial product ingested slowly (SLOW), equivalent carbohydrate as the commercial product ingested with additional fibre (FIBRE), and the commercial product ingested in a dose typically bought (DOSE). These data will provide insight into how the food matrix and different patterns of ingestion can alter the glycaemic response to a fruit smoothie, and how the measurement method may alter interpretations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: 18-65 years
- •Body mass index 18-30 kg/m2
排除标准
- •diagnosis of any form of diabetes
- •intolerances or allergies to any of the study procedures (e.g. fructose/inulin intolerance)
- •Fructose malabsorption
- •Inborn errors of fructose metabolism (e.g. fructokinase deficiency, aldolase B deficiency, fructose-1,6-bisphosphatase deficiency)
- •pregnant or lactating
- •any condition that could introduce bias to the study (e.g. diagnoses of lipid disorders, including cardiovascular disease, or therapies that alter lipid or glucose metabolism, such as statins or niacin).
研究组 & 干预措施
Whole
Apples (51%), Mango (16%), Banana (16%), Orange (12%), Passionfruit (3%), Peach (2%), Lime (0.4%; recipe matched to PRODUCT) eaten as whole fruit with added water as needed to match volume.
干预措施: Food (Other)
Control
50 g glucose (55 g dextrose powder accounting for hydration) plus 417 mL water
干预措施: Food (Other)
Product
417 mL of commercially available "Mango & Passion fruit" fruit smoothie providing 50 g carbohydrate
干预措施: Food (Other)
Blend
Apples (51%), Mango (16%), Banana (16%), Orange (12%), Passionfruit (3%), Peach (2%), Lime (0.4%; recipe matched to PRODUCT) eaten as blended fruit with added water as needed to match volume.
干预措施: Food (Other)
Slow
417 mL of commercially available "Mango and Passionfruit" fruit smoothie providing 50 g carbohydrate ingested slowly over 25-35 mins.
干预措施: Food (Other)
Fibre
417 mL of commercially available "Mango and Passionfruit" fruit smoothie providing 50 g carbohydrate with 6 g of added inulin.
干预措施: Food (Other)
Dose
250 mL of commercially available "Mango and Passionfruit" fruit smoothie providing 30 g carbohydrate.
干预措施: Food (Other)
结局指标
主要结局
Glycaemic index of product with capillary vs CGM
时间窗: 120 min
The difference in glycaemic index \[2-hour incremental area under the curve (mmol/L-1x120 min) for PRODUCT relative to CONTROL expressed as a percentage\] in capillary blood samples versus continuous glucose monitors.
次要结局
- Glycaemic index of all conditions with capillary vs CGM(120 min)
研究者
Javier Gonzalez
Professor of Nutrition and Metabolism
University of Bath