Microvascular Function Assessment in Healthy Subjects

Not Applicable

Completed

• Conditions: Physiology of Microvascular Skin
• Interventions: Drug: Placebo; Drug: acetylsalicilic acids (Aspirin)

• Registration Number: NCT01572961
• Lead Sponsor: University Hospital, Angers

Brief Summary

Current stimulation induces microvascular dilation in human skin. The investigators aimed to study (1) whether the current vasodilation is amplified after two segmental current stimulation as compared to one stimulation; (2) whether this amplification relies on prostaglandin-sensitive mechanisms. A double-blind randomized placebo-controlled crossover trial is conducted in Angers, France.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-11
• Primary Completion: 2012-03
• Study First Submitted: 2012-04-04
• Study First Submitted QC: 2012-04-05
• Study First Posted: 2012-04-06
• Study Completion: 2013-05
• Status Verified: 2016-02
• Last Update Submitted: 2016-02-11
• Last Update Posted: 2016-02-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Age > or equal to 18 years old
• Healthy subjects

Exclusion Criteria

• Aspirin allergy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	Placebo
Aspirin	acetylsalicilic acids (Aspirin)	Aspirin

Primary Outcome Measures

Name	Time	Method
The increase of Laser Doppler Blood Flow after the second current stimulation	1 hour

Secondary Outcome Measures

Name	Time	Method
The increase of Laser Doppler Blood Flow after the second current stimulation after aspirin administration	1 hour

Trial Locations

Locations (1)

University Hospital; 🇫🇷 Angers, Maine et Loire, France