CTRI/2020/06/026006已完成未知
Efficacy of Early terlipressin plus albumin therapy in comparison to standard treatment for HRS-AKI in acute-on-chronic liver failure- A randomized open label study
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 70
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1) Age 18-65 years
- •2) ACLF as per APASL criteria
- •3) AKI at admission as defined by ICA-AKI criteria
- •4) AKI stage 2/3 at 12 hour of admission
排除标准
- •At Admission:
- •1) Age <18 years
- •2) Patients on renal replacement therapy (RRT)
- •3) Post renal or liver transplantation
- •4) History of CAD, ischemic cardiomyopathy, PVD, ventricular arrhythmia
- •5) Decompensated cirrhosis not fulfilling ACLF criteria
- •6) Cirrhotics with AKI managed as outpatients
- •7) Grade III/IV HE or Shock requiring inotropes or patients on mechanical ventilator at time of randomization
- •9) In-hospital new AKI
- •10) Active urinary sediments - 2+ albumin or above, dysmorphic RBCs
- •11) Known CKD, obstructive uropathy
- •12) Lack of informed consent
- •13) Prior intolerance or S/E to Terlipressin or albumin
- •At 12 Hour before randomization:
- •Regression of AKI ( >0.3 mg/dl) above baseline after IV albumin (20% 40 gm) + IV Crystalloids 500 ml therapy for 12 hours
研究者
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