Urinary Tract Infections Rates Using 50% Dextrose Plus Washout Versus Normal Saline as Cystoscopy Fluid

Not Applicable

Completed

• Conditions: Hysterectomy
• Interventions: Procedure: Normal Saline; Procedure: 50% dextrose

• Registration Number: NCT03719755
• Lead Sponsor: Mayo Clinic

Brief Summary

Our study will compare the rates of postoperative urinary tract infections (UTI) between patients who undergo cystoscopy using 50% dextrose injection plus bladder washout versus normal saline after hysterectomy for benign indications. Primary outcome will be rates of urinary tract infections at 6-9 days post-operatively. This will be defined as a urine culture yielding greater than 100,000 gram-negative colony-forming units per milliliter.

Detailed Description

This will be a prospective cohort study of the rate of UTIs after cystoscopic distention media of normal saline with maximum injection of 40 cc of 50% dextrose plus 300 cc of normal saline washout versus normal saline after hysterectomy for benign indications.

A pre-operative urine culture will be obtained via mid-stream clean catch prior to administration of routine pre-operative prophylactic antibiotics.

At 6-9 days post-operatively, a repeat urine culture will be obtained via mid-stream clean catch. Appropriate treatment will be administered if the urine culture is positive.Primary outcome will be rates of urinary tract infections at 6-9 days post-operatively. This will be defined as a urine culture yielding greater than 100,000 gram-negative colony-forming units per milliliter.

Study Timeline

• Study Start: 2018-02-01
• Study First Submitted: 2018-10-19
• Study First Submitted QC: 2018-10-23
• Study First Posted: 2018-10-25
• Primary Completion: 2024-12-30
• Study Completion: 2024-12-30
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-27
• Last Update Posted: 2025-03-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 152

Inclusion Criteria

• Preoperative scheduling CPT codes for hysterectomy

Exclusion Criteria

• Discharged home with indwelling foley catheter
• Indwelling foley catheter > 24 hours
• Ureteral injury
• Chronic immunosuppression
• History of diabetes
• Recurrent UTIs (≥2 infections in six months or ≥3 infections in one year)
• Reported Chronic Kidney Disease
• Renal anomalies

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Normal Saline	Normal Saline	Cystoscopic distention media of normal saline.
50% dextrose	50% dextrose	Cystoscopic distention of 40 cc of 50% dextrose plus 300 cc of normal saline washout

Primary Outcome Measures

Name	Time	Method
rates of urinary tract infections at 6-9 days post-operative	6-9 days post-operative	be rates of urinary tract infections at 6-9 days post-operatively. This will be defined as a urine culture yielding greater than 100,000 gram-negative colony-forming units per milliliter

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Scottsdale, Arizona, United States