To compare the effects of cisatracurium and atracurium on levels of tryptase, Ig E and absolute eosinophil count in adult patients undergoing general anesthesia for elective surgery.
Not Applicable
Completed
- Conditions
- Health Condition 1: O- Medical and SurgicalHealth Condition 2: 8- Other Procedures
- Registration Number
- CTRI/2021/09/036550
- Lead Sponsor
- ABVlMS and Dr RML hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
Consenting adult patients with ASA Grade 1/2
and modified Mallampati grade 1/2
Exclusion Criteria
Patients with anticipated difficult airway.
Patients with peripheral neuropathy, diabetes mellitus, neuromuscular disorders and myopathies.
Patients on antibiotics (e.g., aminoglycosides, tetracyclins, bacitracin, lincomycin, clindamycin, colistin).
Patients on drugs like Magnesium sulphate, lithium, procainamide and quinidine.
Patients with history of atopy and asthma.
Patients with known allergy to any of the drugs involved in study.
pregnant patients.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Patients tryptase levels,IgE levels, absolute eosinophil count, hemodynamic parameters (heart rate and SBP/DBP), cilinical side effects ( flushing of skin, rashes, hypotension, tachycardia, bronchospasm, anaphylaxis, arrhythmias)Timepoint: Blood samples will be taken before induction , one and two hour after giving first dose of study drug and additional sample if and when any side effects occurs.
- Secondary Outcome Measures
Name Time Method nilTimepoint: nil